| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451689 |
| ISSN: | 1984-8250 |
| Authors: | Ekin, Suat1 Yildirim, Serkan2 Akkoyun, Mahire Bayramoglu3 Gok, Hasya Nazli4 Arihan, Okan5 Oto, Gokhan6 Akkoyun, Turan7 Basbugan, Yildiray8 Aslan, Sinem9 |
| Institutions: | 1Van Yuzuncu Yil University, Faculty of Science, Van. Turquía 2Ataturk University, Faculty of Veterinary Medicine, Erzurum. Turquía 3Siirt University, Faculty of Veterinary Medicine, Siirt. Turquía 4Gazi University, Faculty of Pharmacy, Ankara. Turquía 5Hacettepe University, Faculty of Medicine, Ankara. Turquía 6Van Yuzuncu Yil University, Faculty of Medicine, Van. Turquía 7Siirt University, Faculty of Veterinary, Siirt. Turquía 8Van Yuzuncu Yıl University, Faculty of Veterinary Medicine, Van. Turquía 9Ankara University, Faculty of Pharmacy, Ankara. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The purpose of this study was to evaluate the antifibrotic and antioxidant roles of theophylline (Theo), a bioactive compound, in bleomycin (BLM)-induced pulmonary fibrosis in Wistar albino rats. Assigned into 4 groups were 32 Wistar albino rats, comprising the control group (administered 0.9% isotonic saline), BLM group (treated with BLM at a dose of 2.5 mg/kg), BLM+Theo group (treated with Theo at a dose of 75 mg/kg + BLM at a dose of 2.5 mg/kg), and Theo group (treated with Theo at a dose of 75 mg/kg). In the BLM group, a significant decrease was observed in the catalase and glutathione peroxidase enzyme activities, and reduced glutathione (GSH) (p < 0.05, p< 0.05, p< 0.001, respectively), while the malondialdehyde (MDA) levels (p< 0.001) were significantly elevated when compared to the control group. However, the MDA levels in the BLM+Theo group were also significantly higher than in the control group (p< 0.01). Similarly, the GSH levels were significantly higher in the BLM+Theo group than in the BLM group (p< 0.05). The results indicated that Theo reduced the BLM-induced activation of nuclear factor-kappaB (NF-κB) and decreased interleukin-6 (IL-6) levels, together with significant amelioration of the immunohistochemical and histopathological architecture in the lung tissues. It was concluded that the administration of Theo had a positive effect on the GSH level, and activation of NF-κB and IL-6 expression, which were significant proinflammatory markers in the BLM-treated rats |
| Disciplines: | Medicina |
| Keyword: | Medicina experimental, Farmacología, Teofilina, Actividad antioxidante, Estrés oxidativo, Ratas |
| Keyword: | Experimental medicine, Pharmacology, Theophylline, Antioxidant activity, Oxidative stress, Rats |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
