Journal: | Brazilian Journal of Pharmaceutical Sciences |
Database: | PERIÓDICA |
System number: | 000452152 |
ISSN: | 1984-8250 |
Authors: | Aguiar, Patricia M1 Mori, Ana Luiza PM1 Lima, Maria GF de1 Rossi, Magali SPN1 Nicoletti, Maria Aparecida1 Martins, Karina OF2 Lopes, Ana Lúcia M3 Coan, Teresa Cristina M3 Fugita, Oscar Eduardo H3 Storpirtis, Sílvia1 |
Institutions: | 1Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas, Sao Paulo. Brasil 2Secretaria de Saude do Estado de Sao Paulo, Sao Paulo. Brasil 3Universidade de Sao Paulo, Hospital Universitario, Sao Paulo. Brasil |
Year: | 2022 |
Volumen: | 58 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Analítico, descriptivo |
English abstract | This study examined the effects of pharmacist interventions for patients with advanced prostate cancer. A pre-post study was conducted between October 2014 and August 2017 in a community pharmacy in Brazil for outpatients with advanced prostate cancer, aged ≥ 18 years, using cyproterone acetate and/or goserelin. The patients had face-to-face meetings with a pharmacist who dispensed antiandrogenic drugs and performed interventions aimed at solving and/or preventing drug-therapy problems. Primary outcomes regarding prostate-specific antigen (PSA) and testosterone levels were compared at 0, 6, and 12 months, whereas secondary outcomes-medication adherence and quality of life-were compared at baseline and at the 12-month follow-up. Medication adherence was assessed using the Morisky-Green test, and quality of life was measured by the Medical Outcomes Study 36-item Short Form (SF-36) and the Functional Assessment of Cancer Therapy-Prostate (FACT-P). The analysis included 20 patients; 311 drug-therapy problems were identified and most of them were related to adverse reactions (78.5%). The most common adverse reactions were reduced libido, erectile dysfunction, hyperglycemia, fatigue, and gynecomastia. Testosterone levels significantly decreased at 6 months, and PSA levels at 6 and 12 months. No significant changes in adherence were noted at the end of the study. A significant increase in the “pain” domain and an improvement trend in the “physical aspects” and “vitality” domains were observed based on the SF-36 instrument. The findings show that pharmacist interventions were able to improve PSA and testosterone levels, and some domains of quality of life of patients |
Disciplines: | Medicina |
Keyword: | Urología, Oncología, Farmacología, Cáncer, Próstata, Antiandrógenos, Adherencia al tratamiento, Reacciones adversas, Acetato de ciproterona, Goserelina |
Keyword: | Urology, Oncology, Pharmacology, Cancer, Prostate, Antiandrogens, Treatment adherence, Adverse reactions, Cyproterone acetate, Goserelin |
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