| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452135 |
| ISSN: | 1984-8250 |
| Authors: | Yilmaz, Kenan1 Yazici, Selcuk1 Ozcan, Teoman1 Altun, Eren1 |
| Institutions: | 1Balikesir University, Faculty of Medicine, Balikesir. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | We aimed to determine the effects of boric acid and quercetin on contrast media-induced nephropathy in rats. Thirty-two rats were divided into four equal groups with eight rats in each group: the control (C) group, contrast media (CM) group, contrast media plus boric acid (CMB) group, and contrast media plus quercetin (CMQ) group. Boric acid (H3(BO)3, 4% solution) at a dose of 200 mg/kg was administered by oral gavage to rats in the group CMB once daily for 4 consecutive days (days 1 to 4). Quercetin at a dose of 50 mg/kg was administered by oral gavage to rats in the CMQ group once daily for 4 consecutive days (days 1 to 4). A significant decrease was found in the serum urea and creatinine levels in the CMQ group compared with the CM group (P <0.01). The serum nitrite and nitrate levels were higher in the CM group than in the C group and were lower in the CMQ group than in the CM group (P <0.01). A significant decrease in the severity of tubular necrosis was found in the CMQ group compared to the CM group (P <0.05). Quercetin had protective effects against contrast nephropathy, but no beneficial effect of boric acid was found |
| Disciplines: | Medicina |
| Keyword: | Nefrología, Farmacología, Medicina experimental, Nefropatías, Acido bórico, Quercetina, Modelos animales, Ratas |
| Keyword: | Nephrology, Pharmacology, Experimental medicine, Nephropathies, Boric acid, Quercetin, Animal models, Rats |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
