| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451828 |
| ISSN: | 1984-8250 |
| Authors: | Koc, Kubra1 Geyikoglu, Fatime1 Yilmaz, Asli1 Yildirim, Serkan2 Deniz, Gulsah Yildiz3 |
| Institutions: | 1Ataturk University, Faculty of Science, Erzurum. Turquía 2Ataturk University, Faculty of Veterinary, Erzurum. Turquía 3Ataturk University, Vocational School of Health Services, Erzurum. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Epidemiological studies suggest that acute kidney injury has certain effect on myocardial function. In this study, for the first time, we tested a boron compound namely lithium tetraborate an act as an anti-oxidant and anti-inflammatory agent in ischemia-reperfusion injury. For this, we employed an in vivo rat model with kidney ischemia reperfusion injury to evaluate cardiac injury to clarify the mechanisms of lithium tetraborate. The evaluation of cardiac injury through kidney artery occlusion and reperfusion rat model indicated that lithium tetraborate could (1) reduce oxidative stress-induced endothelial dysfunction; (2) attenuate the inflammatory response of cardiac cells; and (3) alleviate the apoptosis and necrosis of myocytes. In summary, lithium tetraborate demonstrates significant therapeutic properties that contribute to the amelioration of cardiac damage, and it could be a promising candidate for future applications in myocardial dysfunction |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Sistema cardiovascular, Nefrología, Isquemia renal, Cardioprotección, Tetraborato de litio |
| Keyword: | Pharmacology, Cardiovascular system, Nephrology, Renal ischaemia, Cardioprotection, Lithium tetraborate |
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