| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452123 |
| ISSN: | 1984-8250 |
| Authors: | Davoodi, Mansooreh1 Nejad Ebrahimi, Samad2 Rustaiyan, Abdolhossein1 Esmaeili, Davoud3 |
| Institutions: | 1Islamic Azad University, Science and Research Branch, Teherán. Irán 2Shahid Beheshti University, Medicinal Plants and Drugs Research Institute, Teherán. Irán 3Baqiyatallah University of Medical Sciences, Systems Biology and Poisonings Institute, Teherán. Irán |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | In the present study, the metabolite profiling of methanolic extract from aerial parts of Satureja khuzistanica Jamzad, as an endemic medicinal plant from Iran, was evaluated using HPLC-PDA-ESI. Then, the main compound from the extract was isolated and purified by using extensive chromatographic techniques. In addition, the structure of the isolated compounds was elucidated using 1D, 2D NMR, and MS spectrometry, upon which 22 compounds were identified. The antibacterial activity of diosmetin 7-rutinoside (6) and linarin (13) in combination with carvacrol as a major compound of the essential oil was tested against Pseudomonas aeruginosa and Staphylococcus aureus through disc diffusion and minimum inhibitory concentration methods. The results indicated that the linarin, when mixed with carvacrol as the main compounds in the essential oil of the plant, has a satisfactory activity against both Pseudomonas aeruginosa and Staphylococcus aureus with MIC values of 0.16 and 0.18 µg/mL, respectively. Further, the fractional inhibitory concentration (FIC) index indicated that this compound had synergism with carvacrol |
| Disciplines: | Química, Biología |
| Keyword: | Angiospermas, Fitoquímica, Flavonoides, Acido cafeico, Actividad antibacteriana, Satureja khuzistanica, Lamiaceae |
| Keyword: | Angiosperms, Phytochemistry, Flavonoids, Caffeic acid, Antibacterial activity, Satureja khuzistanica, Lamiaceae |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
