The antiepileptic activity of Safranal in kindling model of epilepsy in male rats



Document title: The antiepileptic activity of Safranal in kindling model of epilepsy in male rats
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451775
ISSN: 1984-8250
Authors: 1
2
3
2
Institutions: 1Iran University of Medical Sciences, Department of Pharmacology, Teherán. Irán
2Baqiyatallah University of Medical Sciences, Faculty of Pharmacy, Teherán. Irán
3Pasteur Institute of Iran, Department of Physiology and Pharmacology, Teherán. Irán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Recent studies suggested that safranal exerts anticonvulsant properties. The present study aimed to investigate the effect of safranal on epileptic activities in the amygdala electrical kindling model in male rats. Animals were implanted with a recording electrode on the skull and a tripolar in the amygdala. After 10 days of recovery, the afterdischarge (AD) threshold of each animal was determined and stimulated once daily the AD threshold for full kindling development. Then, parameters including afterdischarge duration (ADD), stage 4 latency (S4L), stage 5 duration (S5D), and stimulation threshold were determined before and after injection of safranal (0.05, 0.1, 0.2 ml/ kg; i.p). While the dose of 0.05 ml/kg had no significant effect, the dose of 0.1 ml/kg increased the AD threshold as well as S4L and decreased the S5D (P<0.05). Injection of 0.2 ml/kg of the safranal significantly decreased the ADD and S5D (P<0.05) and 83.3% of animals had no stage 4 and stage 5 of kindling (P<0.001). Based on the obtained data safranal has anticonvulsant effects dosedependently. It seems that a dose of 0.2 ml/kg is the minimum effective dose. Further investigation is warranted to conduct the clinical implications for the treatment of epileptic disorders
Disciplines: Medicina,
Química
Keyword: Farmacología,
Neurología,
Medicina experimental,
Epilepsia,
Convulsiones,
Safranal,
Crocus sativus,
Iridaceae,
Ratas
Keyword: Pharmacology,
Neurology,
Experimental medicine,
Epilepsy,
Seizures,
Safranal,
Crocus sativus,
Iridaceae,
Rats
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