| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451892 |
| ISSN: | 1984-8250 |
| Authors: | Ali, Mahboob4 Avais, Muhammad1 Naheed, Rakhshanda2 Jamal, Muhammad Ameen3 Hasni, Muhammad Sajid1 Ahmad, Mehtab1 Khan, Mumtaz Ali5 Baloch, Sumaira6 Khan, Aman Ullah7 Khan, Samiullah8 Aqib, Amjad Islam9 |
| Institutions: | 1University of Veterinary and Animal Sciences, Lahore, Punjab. Pakistán 2Loralai Medical College, Department of Physiology, Loralai, Baluchistán. Pakistán 3Chinese Academy of Sciences, Kunming Institute of Zoology, Kunming, Yunnan. China 4Animal Sciences Institute, Livestock Dairy Development Department, Quetta, Baluchistán. Pakistán 5Livestock Dairy Development Department, Peshawar, Khyber Pakhtunkhwa. Pakistán 6University of Baluchistán, Quetta, Baluchistán. Pakistán 7College of Veterinary and Animal Sciences, Department of Pathobiology, Jhang. Pakistán 8Yunnan Agricultural University, Kunming College of Animal Science and Technology, Kunming, Yunnan. China 9University of Veterinary and Animal Sciences, Lahore, Punjab. Pakistán |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | This study investigated the synergy testing of penicillin, cephalosporin, amphenicols, and aminoglycoside in the camel milk (n=768 samples), subsequently used for isolation of MDR S. aureus t argeting mecA gene. Antibiotic susceptibility of S. aureus showed >90% isolates were sensitive to ciprofloxacin and trimethoprim and resistant against oxacillin, ampicillin, and cefoxitin. Further, 50-85% of the S. aureus were sensitive to gentamicin, oxytetracycline, and chloramphenicol and resistant against cefotaxime, vancomycin, and cefixime. Minimum inhibitory concentration (MIC) of cefotaxime, (C) and ampicillin (A) in combination with gentamicin (G) was reduced by 99.34% and 70.46%, respectively, while with chloramphenicol (Ch), reduction was 57.49% and 60%, respectively. In addition, the Fractional Inhibitory Concentration Index (FICI) of G+A, Ch+C and Ch+G combinations showed synergy against 80%, 60%, and 30% of MDR S. aureus, respectively. Similarly, C+A and Ch+G displayed indifferent interaction against 70 % and 30% of isolates, respectively, while the later showed additive interaction against 10% of MDR S. aureus. Altogether, our results described effective combination of gentamicin and chloramphenicol with ampicillin and cefotaxime to combat MDR S. aureus |
| Disciplines: | Biología, Química |
| Keyword: | Microbiología, Antibióticos, Sinergismo, Penicilina, Cefalosporinas, Staphylococcus aureus, Ensayos farmacológicos |
| Keyword: | Microbiology, Antibiotics, Synergism, Penicillin, Cephalosporins, Staphylococcus aureus, Pharmacological assays |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
