Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
Document title: Synergistic effect of ibuprofen with itraconazole and fluconazole against Cryptococcus neoformans
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451332
ISSN: 1984-8250
Authors: 1
2
2
1
Institutions: 1Universidade Federal do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil
2Universidade Federal do Rio Grande do Sul, Programa de Pos-Graduacao em Microbiologia Agricola e do Ambiente, Porto Alegre, Rio Grande do Sul. Brasil
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Aplicado, descriptivo
English abstract The present study investigated the association of the non-steroidal anti-inflammatory drug ibuprofen with itraconazole, fluconazole and amphotericin B against Cryptococcus neoformans isolates. The minimal inhibitory concentration (MIC) was found according to M27-A3 protocol and in vitro interactions were evaluated using checkerboard microdilution method. Synergism was demonstrated between azoles and ibuprofen for most isolates. However, no synergistic effects were seen when amphotericin B was combined with ibuprofen. Therefore, our results suggest that ibuprofen presents clinical potential when combined with azole drugs in the treatment of cryptococcosis
Disciplines: Medicina
Keyword: Farmacología,
Microbiología,
Actividad antibacteriana,
Sinergismo,
Ibuprofeno,
Itraconazol,
Fluconazol,
Cryptococcus neoformans
Keyword: Pharmacology,
Microbiology,
Antibacterial activity,
Synergism,
Ibuprofen,
Itraconazole,
Fluconazole,
Cryptococcus neoformans
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