Journal: | Brazilian Journal of Pharmaceutical Sciences |
Database: | PERIÓDICA |
System number: | 000452148 |
ISSN: | 1984-8250 |
Authors: | Udhaya, Lavinya B1 Ubrewe Rutera, Aline1 Ram Kumar, K1 Sangeetha, N1 Manisha, P1 Prince, Sabina Evan1 |
Institutions: | 1Vellore Institute of Technology, School of Biosciences and Technology, Vellore, Tamil Nadu. India |
Year: | 2022 |
Volumen: | 58 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | Gout is a form of metabolic arthritis originated on grounds of increased accumulation of monosodium urate (MSU) crystals in joints. Current study focuses on anti-arthritic activities of β-carotene on MSU crystal-induced gouty arthritis rats in comparison with the non-steroidal anti-inflammatory drug, indomethacin. The evaluation was done by taking into account paw oedema, lysosomal enzymes, anti-oxidant enzymes, lipid peroxidation, serum biochemical parameters (uric acid, creatinine), serum cytokines (TNF-α, IL-1β) and histopathological studies. After the induction of MSU crystals, the lysosomal enzymes were increased, antioxidant enzymes were reduced, lipid peroxidation increased and paw volume increased. β-carotene treated at a dose of 10 mg/kg of body weight stabilizes lysosomal enzymes, increases anti-oxidant enzymes, regulates lipid peroxidation and decreased paw volume. The drug β-carotene potentially influences anti-inflammatory effects in arthritic group which is evident from the reduction in the elevated levels of inflammatory cytokines, TNF-α and IL-1β. Current study is an evidence of anti-inflammatory and anti-oxidant effects of β-carotene against MSU-crystal induced gouty arthritis rats |
Disciplines: | Medicina |
Keyword: | Reumatología, Gota, Artritis, Beta-caroteno, Actividad antiinflamatoria, Actividad antioxidante |
Keyword: | Rheumatology, Gout, Arthritis, Beta-carotene, Anti-inflammatory activity, Antioxidant activity |
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