| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451257 |
| ISSN: | 1984-8250 |
| Authors: | Shan, Yuxia1 Gao, Hui2 Li, Jinghua1 Liu, Yang1 Li, Lujuan1 Zhang, Qi1 |
| Institutions: | 1Dalian Children’s Hospital, Respiratory Ward, Dalian, Liaoning. China 2Dalian Children’s Hospital, Hematology Ward, Dalian, Liaoning. China |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | To find the predictors of High Dose Methotrexate toxicities in childhood Acute Lymphoblastic Leukemia Patients. This study included 198 Childhood Acute Lymphoblastic Leukemia patients (303 infusions) who were treated with High Dose Methotrexate. Methotrexate levels at different time point were measured by modified enzyme multiplied immunoassay technique assay. The correlation between Methotrexate levels and toxicity was evaluated by Receiver Operating Characteristic curve. When the Methotrexate level at 42 h was lower than 0.76 µmol/L, the sensitivity for predicting thorough clearance at 66 h was 90.78%. When the Methotrexate level at 42 h was higher than1.5 µmol/L, the sensitivity for predicting delayed clearance was 82.17%. When the Methotrexate level at 66 h was higher than 0.5 µmol/L, the sensitivity for predicting Methotrexate toxicity was 89.09%. When the Methotrexate level at 66 h was lower than 0.1 µmol/L, the sensitivity for predicting Methotrexate nontoxicity was 92.73%. The Methotrexate level at 42 h could be predictor for delayed clearance. The Methotrexate level at 66 h could be predictor for toxicity |
| Disciplines: | Química, Medicina |
| Keyword: | Farmacología, Oncología, Pediatría, Leucemia linfoblástica aguda, Metotrexato, Toxicidad, Leucovorina |
| Keyword: | Pharmacology, Oncology, Pediatrics, Acute lymphoblastic leukemia, Methotrexate, Toxicity, Leucovorin |
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