| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451511 |
| ISSN: | 1984-8250 |
| Authors: | Montes, Elisangela Gueiber1 Mansani, Fabiana Postiglione2 Schafranski, Marcelo Derbli2 Toledo, Alceu de Oliveira1 Calixto, Lorena de Freitas2 Costa, Rômulo Lopes da2 Staichak, Rodrigo Luiz2 Pinto, Francine Marques2 Berso, Juliane de Lara2 Guimarães, Nicole2 Souza, Marcos Noris Bernardes de2 Zardo, Bruno Queiroz2 Vellosa, José Carlos Rebuglio1 |
| Institutions: | 1Universidade Estadual de Ponta Grossa, Departamento de Analisis Clinicos e Toxicologicos, Ponta Grossa, Parana. Brasil 2Universidade Estadual de Ponta Grossa, Departamento de Medicina, Ponta Grossa, Parana. Brasil |
| Year: | 2021 |
| Volumen: | 57 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Rheumatoid arthritis is an autoimmune inflammatory joint disease with global prevalence of 0.4% to 1.0%. Extra-articular manifestations increase its morbidity and severity, and cardiovascular diseases present the greatest risk. Therapeutic approaches have been used to treat rheumatoid arthritis, often involving the use of multiple classes of drugs with different mechanisms and forms of action. Corticosteroid therapy is widely used in this therapeutic combination; however, its use has been widely questioned because of its high toxicity and some negative effects, including the possibility of increased cardiovascular risk, depending on the dosage. Some studies have provided important insights into how glucocorticoids have an impact on cardiac complications in patients with rheumatoid arthritis. Most of these studies have concluded that exposure to these drugs at high or cumulative doses is associated with increased risk of death, as well as possibly being associated with the presence of a positive rheumatoid factor |
| Disciplines: | Medicina |
| Keyword: | Reumatología, Farmacología, Artritis reumatoide, Corticoterapia, Glucocorticoides, Riesgo cardiovascular |
| Keyword: | Rheumatology, Pharmacology, Rheumatoid arthritis, Cardiovascular risk, Corticotherapy, Glucocorticoids |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
