| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451351 |
| ISSN: | 1984-8250 |
| Authors: | Cakır, Tahir1 Yıldızhan, Kenan1 Huyut, Zübeyir1 Uyar, Ahmet2 Arıhan, Okan1 |
| Institutions: | 1Van Yuzuncu Yil University, Medical Faculty, Van. Turquía 2Van Yuzuncu Yil University, Faculty of Veterinary, Van. Turquía |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | It was aimed to investigate the radioprotective activity of Urtica dioica L. seed extract (UDSE) in the whole blood and liver of radiation-administered rats, both biochemically and immunohistochemically. 32 rats were divided into 4 groups (n:8). Control group (C): no administration for 10 days. Radiation group (IR): fed pellets for 10 days after exposure to radiation. Radiation + UDSE (IR+UDSE) group: exposed to radiation and fed UDSE for 10 days. UDSE group (UDSE): fed UDSE for 10 days. Radiation (5Gy) was given as a single fraction. 8-hydroxy-2-deoxyguanosine (8-OHdG) and deoxyguanosine (dG) levels were analyzed by biochemical method and glutathione peroxidase 1 (GPx-1) analyses were performed by immunohistochemical method in the liver and blood tissues of the rats. The increased 8-OHdG rates and decreased GPx-1 immunoreactivity was observed in the IR group. Those parameters were ameliorated in the IR+UDSE group when compared to the IR group. UDSE is likely to be a valuable radioprotector against the harmful effects of radiation |
| Disciplines: | Biología, Química |
| Keyword: | Farmacología, Medicina experimental, Semillas, Extractos vegetales, Daño al ADN, Antioxidantes, Radioprotección, Urtica dioica, Urticaceae |
| Keyword: | Pharmacology, Experimental medicine, Seeds, Plant extracts, DNA damage, Antioxidants, Radioprotection, Urtica dioica, Urticaceae |
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