Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats
Document title: Protective effects of Urtica dioica L. seed extract on liver tissue injury and antioxidant capacity in irradiated rats
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451428
ISSN: 1984-8250
Authors: 1
2
3
1
1
4
4
Institutions: 1Van Yuzuncu Yil University, Medical Faculty, Van. Turquía
2Gaziantep University, Medical Faculty, Gaziantep. Turquía
3Mustafa Kemal University, Faculty of Veterinary, Hatay. Turquía
4Van Yuzuncu Yil University, Faculty of Veterinary, Van. Turquía
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Radiotherapy is often used for the treatment of cancer. However, it causes some side effects in patients. This study aimed to determine the hepatoprotective effects of Urtica dioica L. seed-extract (UDSE) in radiation-induced liver injury. Thirty-two male rats were randomly divided into 4 groups (n=8): control(C) group: no action was taken; radiation (R) group: irradiation was administrated at 5Gy single-fraction, radiation with UDSE(R+UDSE) group: irradiation was administrated at 5 Gy single-fraction and animals were fed pellets with 30 mL UDSE/kg; UDSE group: animals were fed pellets with 30 mL UDSE/kg. All of the experiments were performed in all of the groups over 10 days. Malondialdehyde (MDA) and reduced-glutathione (GSH) levels and superoxide-dismutase (SOD), catalase (CAT), glutathione-peroxidase (GSH-Px), aspartate-transaminase (AST), and alanine-aminotransferase (ALT) activities were determined. Histopathological findings were also evaluated in liver tissues. SOD, CAT and GSH-Px activities and GSH levels in the serum and liver were significantly increased, while MDA levels decreased in the R+UDSE group compared with the R group (P<0.05). Moreover, AST and ALT serum activities in the R+UDSE group were lower than those in the R group (P<0.05). In addition, radiation induced degenerative/necrotic changes in the R group were significantly compensated in the R+UDSE group. The results showed that radiation increased oxidative stress and decreased antioxidant capacity, as well as degeneration in the liver. However, UDSE attenuated these degenerative changes
Disciplines: Medicina,
Química
Keyword: Medicina experimental,
Farmacología,
Semillas,
Extractos vegetales,
Radioterapia,
Efectos adversos,
Efecto protector,
Estrés oxidativo,
Daño tisular,
Urtica dioica,
Urticaceae
Keyword: Experimental medicine,
Pharmacology,
Seeds,
Plant extracts,
Radiotherapy,
Adverse effects,
Protective effect,
Urtica dioica,
Urticaceae,
Oxidative stress,
Tissue injury
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