| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451749 |
| ISSN: | 1984-8250 |
| Authors: | Aquino, Jéssica Azevedo1 Oliveira, Cláudia Lorenzo1 Otoni, Alba1 Sanches, Cristina2 Guedes, João Victor Marques1 Morais, Diego Bruno3 Mendonça, Thays Santos1 Morais, Flávio Augusto4 Baldoni, André Oliveira1 |
| Institutions: | 1Universidade Federal de Sao Joao del Rei, Programa de Pos-graduacao em Ciencias da Saude, Divinopolis, Minas Gerais. Brasil 2Universidade Federal de Sao Joao del Rei, Programa de Pos-graduacao em Ciencias Farmaceuticas, Divinopolis, Minas Gerais. Brasil 3Universidade Federal de Sao Joao del Rei, Campus Centro Oeste Dona Lindu, Divinopolis, Minas Gerais. Brasil 4Departamento de Saude Municipal de Divinopolis, Divinopolis, Minas Gerais. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Evidence on factors associated with the progression of chronic kidney disease (CKD) is still under construction. The present study aimed to evaluate sociodemographic, clinical, and drug use factors associated with the progression of CKD. A retrospective cohort study was conducted with 193 patients with CKD stages 3A to 5- non-dialysis followed for three years in a Brazilian city. The outcome was the evolution to renal replacement therapy (RRT) or death. A total of 52.3 % (n = 101) were men and 83.4 % (n = 161) elderly. The median age was 72.0 years, and 22.3 % (n = 44) progressed to RRT or death, and the three-year mortality rate was 20.2 %. Participants exposed to angiotensin converting enzyme inhibitors or angiotensin II receptor blockers had a lower risk of progressing to the outcome (hazard ratio (HR) 0.25; p = 0.003) and higher survival (p = 0.022) when compared to those not exposed to these drugs. Age (HR 1.06;) and use of omeprazole (HR 6.25; CI; p <0.01) and hydrochlorothiazide (HR 2.80; p = 0.028) increased the risks of RRT or death. The results highlight the importance of rational management of pharmacotherapy for patients with CKD |
| Disciplines: | Medicina |
| Keyword: | Nefrología, Farmacología, Enfermedad renal crónica, Farmacoterapia |
| Keyword: | Nephrology, Pharmacology, Chronic kidney disease, Drug therapy |
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