Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite
Document title: Potential Alendronate Sodium drug carrier by preparation and characterization of sodium alginate cross-linked Montmorillonite
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451752
ISSN: 1984-8250
Authors: 1
1
2
Institutions: 1Islamic Azad University, Tehran Science and Research Branch, Teherán. Irán
2Islamic Azad University, Lahijan Branch Nano Research Laboratory, Lahijan. Irán
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract In drug therapy, it is important to provide therapeutic levels of drug to the site of action and maintain them during the treatment. This work describes the in vitro release of alendronate from sodium alginate cross-linked Montmorillonite (MMT) composite beads. Effect of crosslinking cation, concentration of montmorillonite and media on encapsulation efficiencies, and release profiles of alendronate were studied. Beads were characterized using equilibrium swelling ability study, Fourier transform infrared spectroscopy (FTIR), X-ray diffraction (XRD), Energy-dispersive x-ray spectroscopy (EDX) and scanning electron microscopy (SEM). Results indicate that addition of montmorillonite increases the encapsulation efficiencies and slows down the release rates significantly
Disciplines: Química
Keyword: Química farmacéutica,
Alendronato de sodio,
Liberación de fármacos,
Acarreadores,
Alginato de sodio,
Montmorillonita
Keyword: Medicinal chemistry,
Sodium alendronate,
Drug delivery,
Carriers,
Sodium alginate,
Montmorillonite
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