| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451227 |
| ISSN: | 1984-8250 |
| Authors: | Abbas, Nasir1 Irfan, Muhammad2 Zahoor, Ameer Fawad4 Khan, Ikram Ullah3 Syed, Haroon Khalid3 Rasul, Akhtar3 Hussain, Amjad1 Arshad, Mohammad Sohail5 Mohsin, Noor ul amin4 Iqbal, Furqan Muhammad5 Qayyum, Muhammad Abdul6 |
| Institutions: | 1University of the Punjab, University College of Pharmacy, Lahore, Punjab. Pakistán 2Freie Universität Berlin, College of Pharmacy, Berlín. Alemania 3GC University Faisalabad, Faculty of Pharmaceutical Sciences, Faisalabad, Punjab. Pakistán 4GC University Faisalabad, Department of Chemistry, Faisalabad, Punjab. Pakistán 5Bahauddin Zakriya University, Department of Pharmacy, Multan, Punjab. Pakistán 6University of Education, Department of Chemistry, Lahore, Punjab. Pakistán |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of present work was to investigate blends of Eudragit® NE 30D with Aquacoat® ECD using different ratios to eliminate curing effect associated with individual polymers. Propranolol HCl 10% w/w was layered onto sugar cores using 5% w/w HPMC as a binder. Drug-layered-cores were coated either with pure or blends of Aquacoat® ECD: Eudragit® NE 30D in a fluidized bed coater to obtain 20% w/w coating level. Talc 35% w/w was used as anti-tacking agent. The pellets were characterized for in vitro dissolution studies, morphology, water uptake-weight loss, osmolality and adhesion of coating after curing at 60 °C or 60 °C/75% RH for 24 h. The findings revealed that Aquacoat® ECD coated pellets showed curing effect due to further gradual coalescence of polymeric particles which resulted into better film formation upon curing. In contrast, the curing effect of Eudragit® NE 30D coated pellets was caused by decrease in adhesion of coatings after curing which provided entirely different swelling behavior of uncured (localized swelling) and cured (uniform swelling) pellets. The undesired curing effect of individual polymers was eliminated by using their blends in appropriate ratio |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Mezcla polimérica, Recubrimientos de dispersión acuosa, Pellets recubiertos, Efecto de cura, Adhesión |
| Keyword: | Medicinal chemistry, Polymer blends, Aqueous dispersion coatings, Coated pellets, Curing effect, Adhesion |
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