| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451897 |
| ISSN: | 1984-8250 |
| Authors: | Ribeiro, Priscilla Tobias1 Pedrosa, Tatiana do Nascimento2 Chaves, Francisco Celio Maia3 José, Lucindo4 Araújo, Adriano Antunes de Souza4 Vasconcellos, Marne Carvalho de1 Maria Engler, Silvya Stuchi2 Silva, Cláudia Cândida5 Silva, Felipe Moura Araújo da6 Koolen, Héctor Henrique Ferreira5 Lima, Emerson Silva1 Lima, Ádley Antonini Neves de7 |
| Institutions: | 1Universidade Federal do Amazonas, Faculdade de Ciencias Farmaceuticas, Manaus, Amazonas. Brasil 2Universidade de Sao Paulo, Faculdade de Ciencias Farmaceuticas, Sao Paulo. Brasil 3Empresa Brasileira de Pesquisa Agropecuaria, Manaus, Amazonas. Brasil 4Universidade Federal de Sergipe, Departamento de Ciencias Farmaceuticas, Sao Cristovao, Sergipe. Brasil 5Universidade do Estado do Amazonas, Escola Superior de Tecnologia,, Manaus, Amazonas. Brasil 6Universidade do Estado do Amazonas, Escola Superior de Ciencias da Saude, Manaus, Amazonas. Brasil 7Universidade Federal do Rio Grande do Norte, Departamento de Ciencias Farmaceuticas, Natal, Rio Grande do Norte. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | Passiflora nitida Kunth, an Amazonian Passiflora species, is little studied, although the specie’s high biological potential. Herein the plant’s pharmacognostic characterization, extract production, antioxidant potential evaluation, and application of this extract in cosmetic products is reported. The physical chemical parameters analyzed were particle size by sieve analysis, loss through drying, extractive yield, total ash content, laser granulometry, specific surface area and pore diameter (SBET), differential scanning calorimetry, thermogravimetry (TG), and wave dispersive X-Ray fluorescence (WDXRF). Total phenol/flavonoid content, LC-MS/MS analysis, DPPH and ABTS antioxidant radical assays, cytotoxicity, melanin, and tyrosinase inhibition in melanocytes test provided evidence to determine the content of the major constituent. P. nitida dry extract provided a fine powder with mesopores determined by SBET, with the TG curve showing five stages of mass loss. The antioxidant potential ranged between 23.5-31.5 mg∙mL-1 and tyrosinase inhibition between 400-654 μg∙mL-1. The species presented an antimelanogenic effect and an inhibitory activity of cellular tyrosinase (26.6%) at 25 µg/mL. The LC-MS/MS analysis of the spray-dried extract displayed the main and minor phenolic compounds constituting this sample. The results indicate that P. nitida extract has promising features for the development of cosmetic formulations |
| Disciplines: | Química |
| Keyword: | Fitoquímica, Farmacología, Productos naturales, Cosméticos, Antioxidantes, Inhibidores enzimáticos, Tirosinasa, Passiflora nitida, Passifloraceae |
| Keyword: | Phytochemistry, Pharmacology, Natural products, Antioxidants, Cosmetics, Enzyme inhibitors, Tyrosinase, Passiflora nitida, Passifloraceae |
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