| Journal: | Brazilian journal of pharmaceutical sciences |
| Database: | PERIÓDICA |
| System number: | 000366916 |
| ISSN: | 1984-8250 |
| Authors: | Xue, Hefei1 Li, Yuzhong2 Zhang, Wenjie1 Lu, Dongrui1 Chen, Yinghui1 Yin, Jingjing1 Meng, Yihan1 Ying, Xixiang1 Kang, Tingguo1 |
| Institutions: | 1Liaoning University of Traditional Chinese Medicine, School of Pharmacy, Dalian, Liaoning. China 2Second Affiliated Hospital of Dalian Medical University, Department of Inspection, Dalian, Liaoning. China |
| Year: | 2013 |
| Season: | Jul-Sep |
| Volumen: | 49 |
| Number: | 3 |
| Pages: | 435-441 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of this study is to develop a simple and specific HPLC method using vitexin as the internal standard to investigate the pharmacokinetics of isoquercitrin (ISOQ) after three different doses administrated intravenously to rats. The pharmacokinetic parameters were calculated by both compartmental and non-compartmental approaches. The results showed that ISOQ fitted a three-compartment open model. The values of AUC increased proportionally within the range of 5-10 mg·kg-1. Moreover, a half-life, b half-life, ªCL, MRT0-t and MRT0→∞ of ISOQ in rats showed significant differences between 20 mg·kg-1 and other doses, indicating that ISOQ presented dose-dependent pharmacokinetics in the range of 5-10 mg·kg-1 and non-linear pharmacokinetics at higher doses |
| Portuguese abstract | O objetivo deste estudo é desenvolver um método simples e específico de HPLC usando vitexina como padrão interno para investigar a farmacocinética do isoquercitrina (ISOQ) após três doses diferentes administradas por via intravenosa a ratos. Os parâmetros farmacocinéticos foram calculados pelas abordagens compartimental e não compartimental. Os resultados mostraram que ISOQ se encaixa no modelo de três compartimentos. Os valores de AUC aumentaram proporcionalmente na faixa de 5-10 mg·kg-1. Além disso, a meia-vida, b meia-vida, ªCL, MRT0-t and MRT0→∞ de ISOQ em ratos mostraram diferenças significativas entre 20 mg·kg-1 e outras doses, o que significa que ISOQ apresenta farmacocinética dose-dependente no intervalo de 5-10 mg·kg-1 e farmacocinética não linear em doses mais elevadas |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Isoquercitrina, Farmacocinética, Crataegus pinnatifida, Plantas medicinales |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Isoquercitrin, Pharmacokinetics, Crataegus pinnatifida, Medicinal plants |
| Full text: | Texto completo (Ver HTML) |
