| Journal: | Brazilian journal of pharmaceutical sciences |
| Database: | PERIÓDICA |
| System number: | 000376301 |
| ISSN: | 1984-8250 |
| Authors: | Sohail, Kashif1 Khan, Ikram Ullah2 Shahzad, Yasser3 Hussain, Talib4 Ranjha, Nazar Muhammad1 |
| Institutions: | 1Bahauddin Zakariya University, Faculty of Pharmacy, Multan. Pakistán 2Universite de Strasbourg, Laboratoire de conception et l'application de molecules bioactives, Strasbourg, Haut-Rhin. Francia 3Government College University, College of Pharmacy, Faisalabad. Pakistán 4University of Huddersfield, Division of Pharmacy and Pharmaceutical Sciences, Huddersfield. Reino Unido |
| Year: | 2014 |
| Season: | Ene-Mar |
| Volumen: | 50 |
| Number: | 1 |
| Pages: | 173-184 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels |
| Portuguese abstract | In this study, we fabricated pH-sensitive polyvinylpyrrolidone/acrylic acid (PVP/AA) hydrogels by a free-radical polymerisation method with variation in the content of monomer, polymer and cross-linking agent. Swelling was performed in USP phosphate buffer solutions of pH 1.2, 5.5, 6.5 and 7.5 with constant ionic strength. Network structure was evaluated by different parameters and FTIR confirmed the formation of cross-linked hydrogels. X-ray crystallography showed molecular dispersion of tramadol HCl. A drug release study was carried out in phosphate buffer solutions of pH 1.2, 5.5 and 7.5 for selected samples. It was observed that swelling and drug release from hydrogels can be modified by changing composition and degree of cross-linking of the hydrogels under investigation. Swelling coefficient was high at higher pH values except for the one containing high PVP content. Drug release increased by increasing the pH of the medium and AA contents in hydrogels while increasing the concentration of cross-linking agent had the opposite effect. Analysis of the drug release mechanism revealed non-Fickian transport of tramadol from the hydrogels |
| Disciplines: | Química |
| Keyword: | Química de polímeros, Química farmacéutica, Fármacos, Liberación, Hidrogeles, pH sensibles, Acido acrílico hidrogels polivinilpirrolidona, Clorhidrato de tramadol, Bisacrilamida de metileno |
| Keyword: | Chemistry, Medicinal chemistry, Polymer chemistry, Drugs, Release, Hydrogels, pH sensitive, Polyvinylpyrrolidone-acrilic acid, Tramadol hydrochloride, Methylene bisacrylamide |
| Full text: | Texto completo (Ver PDF) |
