| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452201 |
| ISSN: | 1984-8250 |
| Authors: | Chaves, Elana Figueiredo1 Alcântara, José Martins de1 Moreira, Lívia Maria Porto1 Medeiros, Pedro Henrique Quintela Soares de2 Firmino, Paulo Andrei Milen3 Abreu, Gabriela Araújo de1 Bastos, Angelina Almeida1 Peixoto, Arnaldo Aires3 Guedes, Marjorie Moreira1 |
| Institutions: | 1Universidade Federal do Ceara, Hospital Universitario Walter Cantidio, Fortaleza, Ceara. Brasil 2Universidade Federal do Ceara, Faculdade de Medicina, Fortaleza, Ceara. Brasil 3Universidade Federal do Ceara, Faculdade de Farmacia, Odontologia e Enfermagem, Fortaleza, Ceara. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | The objective of this study was to determine the prevalence and describe the factors associated with off-label drug use in an adult intensive care unit (ICU) of a Brazilian hospital. An analytical, cross-sectional, prospective study was conducted in the adult ICU population from March 2018 to May 2018. Off-label use of medication was classified by indication, dosage, route of administration, type and volume of diluent, and duration of administration. Most patients were female (57.89%), non-elderly (56.14%), and had a mean age of 54.44 ± 17.15 years. The prevalence of off-label drug use was 70.31%, but was not associated with the clinical severity of the patients. A statistically significant association was observed between label use of drugs and prescribing potentially inappropriate medicines (PIM). The most common reasons for off-label drug use were therapeutic indication (19.58%) and volume of diluent (23.30%). Drug administration by enteral tubes accounted for the largest number of off-label uses due to route of administration (90.85%). There was a higher prevalence of off-label use of systemic antimicrobials (14.44%) and norepinephrine (9.28%). Our study provided a broad characterization of off-label drug use in an adult ICU and showed why it is important for health professionals to evaluate the specific risks and benefits of this practice |
| Disciplines: | Medicina |
| Keyword: | Hospitales, Farmacología, Unidad de cuidados intensivos, Uso de medicamentos |
| Keyword: | Hospitals, Pharmacology, Intensive care unit (ICU), Drugs use |
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