| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451326 |
| ISSN: | 1984-8250 |
| Authors: | Martins, Tathiana Silva de Souza Figueras, Albert1 Souza, Luana dos Reis de2 Santos, Keila Cristina Oliveira dos2 Oliveira, Elaine Machado de3 Secoli, Silvia Regina3 |
| Institutions: | 1Universidad Autónoma de Barcelona, Departamento de Farmacología, Barcelona. España 2Instituto Pediatrico Martagao Gesteira, Rio de Janeiro. Brasil 3Universidade de Sao Paulo, Escola de Enfermagem, Sao Paulo. Brasil |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | To evaluate the clinical outcomes of daptomycin therapy and adherence to treatment recommendations, a retrospective cohort study was conducted with patients that received daptomycin during the period of the study. The adherence and nonadherence to clinical guidelines were assessed through organism identification, dose and time of treatment, management of bacteremia, and vancomycin treatment failure. A multiple logistic regression model analyzed the association between independent variables and clinical success (dependent variable), considering 5% of statistical significance. The study presented 52 patients who received daptomycin for the treatment of bacteremia (21.1%) or infections (osteomyelitis [63.5%], synovial fluid [15.4%]). Most patients (86.5%) received daptomycin as the second line of treatment, and 51.9% achieved clinical success. The patients had a better chance of clinical success when they followed the guideline indications (OR = 16.86; 95% CI = 1.45-195.88) and the medication was prescribed by a specialist in infectious diseases (OR = 4.84; 95% CI = 1.11-21.09). The study demonstrated lower clinical success than that described in the literature because of patients who were not eligible according to the clinical guidelines. Adherence to recommendations and appropriate prescription of reserve antibiotics is important in limiting early resistance, and avoiding clinical failure and unnecessary expenditure |
| Disciplines: | Medicina |
| Keyword: | Traumatología y ortopedia, Farmacología, Infecciones óseas, Antibióticos, Daptomicina, Adherencia al tratamiento |
| Keyword: | Traumatology and orthopedics, Pharmacology, Bone infections, Daptomycin, Antibiotics, Treatment adherence |
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