| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452187 |
| ISSN: | 1984-8250 |
| Authors: | Archana, Jorige1 Annapurna, Akula2 Devayani, Panuganti3 |
| Institutions: | 1Osmania University, RBVRR Women’s College of Pharmacy, Hyderabad, Telangana. India 2Andhra University, University College of Pharmaceutical Sciences, Visakhapatnam, Andhra Pradesh. India 3Indian Institute Of Chemical Technology, Hyderabad, Andhra Pradesh. India |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Diabetic Neuropathy (DN) is one of the prevailing micro vascular complications of diabetes which can be characterized by neuropathic pain. Streptozotocin (STZ) induced diabetes in the rat has been increasingly used as a model of painful diabetic neuropathy. STZ injection leads to neurotoxicity of peripheral nerves that leads to development of Peripheral Diabetic Neuropathy in rat model. The present study was aimed at exploring the protective role of Tinospora cordifolia extract in STZ induced neurotoxicity and evaluating mechanisms responsible for attenuating neuropathic pain. Neuropathic pain markers like hyperalgesia, allodynia and motor deficits were assessed before STZ injection and after the treatment with 250 mg/kg and 500 mg/kg dose of Tinospora cordifolia. Oxidative stress markers, NGF expression in sciatic nerve were observed after seven weeks treatment. Our results demonstrated that seven weeks treatment with Tinospora cordifolia leaf extract significantly relieved thermal hyperalgesia and allodynia by increasing the antioxidant enzyme levels, decreasing the lipid peroxidation and by increasing the Nerve growth factor (NGF) expression in diabetic rat sciatic nerves. Our findings highlighted the beneficial effects of oral administration of Tinospora cordifolia extract in attenuating diabetic neuropathic pain, possibly through a strong antioxidant activity and by inducing NGF m RNA in sciatic nerves |
| Disciplines: | Química |
| Keyword: | Fitoquímica, Farmacología, Extractos vegetales, Hiperalgesia, Alodinia, Dolor neuropático, Tinospora cordifolia, Menispermaceae |
| Keyword: | Phytochemtry, Pharmacology, Plant extracts, Hyperalgesia, Allodynia, Neuropathic pain, Tinospora cordifolia, Menispermaceae |
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