Nesiritide protects endothelial function after balloon-induced trauma in the iliac artery in rabbits
Document title: Nesiritide protects endothelial function after balloon-induced trauma in the iliac artery in rabbits
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451341
ISSN: 1984-8250
Authors: 1
2
2
1
2
Institutions: 1Shandong University, Shandong Provincial Hospital, Jinan, Shandong. China
2Liaocheng People’s Hospital, Department of Cardiology, Liaocheng, Shandong. China
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract To assess the effect of nesiritide on the endothelial function of iliac arteries following endothelia trauma. Right iliac artery trauma was created with a balloon catheter. Ten rabbits were treated with a 4-week subcutaneous injection of nesiritide at a fixed daily dose of 0.1mg/kg. Ten rabbits received daily normal saline injection. Plasma endothelin 1 (ET-1), nitric oxide (NO), and Von Willebrand Factor (vWF) were measured before and after the therapies. Tissue proliferating cell nuclear antigen (PCNA) was measured after the treatment. After the treatment, in the therapeutic group, the area under internal elastic membrane and the residual lumen area were higher than in the normal saline group (P <0.05). The plasma levels of ET-1 (91.6±6.8 vs 114.9±6.3 ng/L, P =0.001), vWF (134.6±10.8% vs 188.8±10.4%, P =0.001) and the ratio of PCNA positive expression (11.7±4.2% vs 36.2±11.4%, P =0.005) in the therapeutic group was lower than in the normal saline group, while the plasma levels of NO was higher (89.7±9.3 vs 43.5±5.3 µmol/L, P =0.001). Nesiritide inhibited remodeling of rabbit iliac artery following endothelial trauma. The inhibition of vascular remodeling may be related to the alleviated endothelial dysfunction and reduced expression of tissue proliferating cell nuclear antigen
Disciplines: Química,
Medicina
Keyword: Medicina experimental,
Sistema cardiovascular,
Farmacología,
Nesiritida,
Lesiones arteriales,
Efecto protector,
Función endotelial,
Endotelina plasmática,
Oxido nítrico,
Factor de von Willebrand
Keyword: Experimental medicine,
Cardiovascular system,
Pharmacology,
Nesiritide,
Arterial lesions,
Protective effect,
Endothelial function,
Plasma endothelin,
Nitric oxide,
Von Willebrand factor
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