Journal: | Brazilian journal of pharmaceutical sciences |
Database: | PERIÓDICA |
System number: | 000388313 |
ISSN: | 1984-8250 |
Authors: | Ahmad, Saeed1 Khaliq, Farhan Hameed1 Madni, Asadullah1 Shahid, Muhammad Nabeel2 Pervaiz, Irfan1 |
Institutions: | 1The Islamia University of Bahawalpur, Faculty of Pharmacy and Alternative Medicine, Bahawalpur, Punjab. Pakistán 2Superior Group of Colleges, Department of Pharmaceutical Sciences, Lahore, Punjab. Pakistán |
Year: | 2014 |
Season: | Oct-Dic |
Volumen: | 50 |
Number: | 4 |
Pages: | 903-909 |
Country: | Brasil |
Language: | Inglés |
Document type: | Artículo |
Approach: | Experimental, aplicado |
English abstract | In the present research, the steroidal anti-asthmatic drug beclomethasone dipropionate was subjected to microbial biotransformation by Aspergillus niger. Beclomethasone dipropionate was transformed into various metabolites first time from microbial transformation. New drug metabolites produced can act as new potential drug molecules and can replace the old drugs in terms of safety, efficacy, and least resistance. They were purified by preparative thin layer chromatography technique, and their structures were elucidated using modern spectroscopic techniques, such as 13C NMR, 1H NMR, HMQC, HMQC, COSY, and NOESY, and mass spectrometry, such as EI-MS. Four metabolites were purified: (i) beclomethasone 17-monopropionate, (ii) beclomethasone 21-monopropionate, (iii) beclomethasone, and (iv) 9beta,11beta-epoxy-17,21-dihydroxy-16beta-methylpregna-1,4-diene-3,20-dione 21-propionate |
Portuguese abstract | Na pesquisa presente o fármaco esteróide antiasmático dipropionato de beclometasona foi submetido à biotransformação microbiana pelo Aspergillus niger. O dipropionato de beclometasona foi transformado, pela primeira vez, em metabólitos variados por biotransformação microbiana. Novos metabólitos do fármaco produzidos podem agir como novas moléculas potenciais e podem substituir os fármacos antigos em questão de segurança, eficácia e mínima resistência. Eles foram purificados por cromatografia em camada delgada preparativa e as suas estruturas foram elucidadas usando técnicas espectroscópicas modernas, como 13C NMR, 1H NMR; HMQC; HMQC; COSY, NOESY e espectrometria de massas, por exemplo, EI-MS. Purificaram-se quatro metabólitos, denominados (i) 17-monopropionato de beclometasona; (ii) 21-monopropionato de beclometasona: (iii) beclometasona e (iv) 21-propionato de 9beta,11beta-epoxi-17,21-diidroxi-16beta-metilpregna-1,4-dieno-3,20-diona |
Disciplines: | Química |
Keyword: | Química farmacéutica, Antiasmáticos, Esteroides, Transformación microbiológica, Aspergillus niger, Dipropionato de beclometasona |
Keyword: | Chemistry, Medicinal chemistry, Anti-asthmatic agents, Steroids, Microbiological transformation, Aspergillus niger, Beclomethasone dipropionate |
Full text: | Texto completo (Ver HTML) |