| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452227 |
| ISSN: | 1984-8250 |
| Authors: | Rahman, Anisur1 Ibrahim, Mohammad2 Siddiqui, Javed Inam3 Ansari, Shafeeque Ahmed1 Ahmad, Sayeed2 |
| Institutions: | 1Jamia Millia Islamia, Department of Biotechnology, Nueva Delhi, Delhi. India 2Jamia Hamdard School of Pharmaceutical Education and Research, Bioactive Natural Product Laboratories, Nueva Delhi, Delhi. India 3Central Institutes for Research in Unani Medicine, Department of IlmulAdvia (Pharmacology), Hyderabad, Telangana. India |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Rumex vesicarius has been extensively used for the management of diabetes in the traditional system of medicine. The current study was designed to investigate antidiabetic and antihyperlipidemic effects of R.vesicarius and also to explore metabolomic profiling using UPLC-QTOF-MS. The effect of extracts was observed by checking the biochemical and histopathological parameters in diabetic rats. The results had shown a significant dose- dependent inhibition potential of aqueous extract of R. vesicarius seed against α-amylase and α-glucosidase along with significant inhibition in DPPH free-radical scavenging activity. Oral administration of R. vesicarius to diabetic rats significantly ( p< 0.05) ameliorated blood glucose level. It also improved the function of the liver and kidney as well as ameliorated dyslipidemia in diabetic rats. Histopathological examination of the treatment groups reversed the damage of the pancreas, liver, and kidney tissues confirming the antidiabetic efficacy of R. vesicarius. UPLC- QTOF-MS analysis of the extract revealed a total of 42 bioactive compounds, which might contribute to the antidiabetic activity. Based on our findings, we can conclude that R. vesicarius might be a promising candidate for the management of diabetes |
| Disciplines: | Medicina |
| Keyword: | Endocrinología, Farmacología, Medicina experimental, Diabetes, Plantas medicinales, Metabolómica, Rumex vesicarius, Polygonaceae |
| Keyword: | Endocrinology, Pharmacology, Experimental medicine, Diabetes, Medicinal plants, Metabolomics, Rumex vesicarius, Polygonaceae |
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