| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451430 |
| ISSN: | 1984-8250 |
| Authors: | Silva, Mayara Christine1 Matos, Aline Ferreira1 Santos, Hataânderson Luíz Cabral dos1 Gomes, Jennifer Vieira1 Pastura, Danilo Giovanni Narciso1 Pereira, Gabriela Lopes1 Rocha, Ellen Borges da1 Larangeira, Mayara de Jesus Costa1 Alves, Raphael Santiago1 Bastos, Leonardo de Oliveira1 Borba, Helcio Resende1 Lima, Viviane Moreira de1 |
| Institutions: | 1Universidade Federal Rural do Rio de Janeiro, Instituto de Ciencias Biologicas e da Saude, Seropedica, Rio de Janeiro. Brasil |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Laurus nobilis L. is a large shrub belonging to the Lauracea family. Its leaves are widely used for food seasoning as well as in folk medicine. Various studies have demonstrated the antiproliferative, antifungal and antibacterial effects of Laurus nobilis, but no studies have investigated the genotoxic effect of the aqueous extract of the plant. The objective of this study was to analyze the genotoxic potential of an aqueous extract of leaves, using the Allium cepa assay and mouse peripheral blood cell micronucleus test. The results showed that the extract did not have any genotoxic activity, but cytotoxic activity was observed in the two experimental models used. The extract had an antiproliferative effect, detected through the reduction of the mitotic index and the polychromatic/normochromatic erythrocyte (PCE/NCE) ratio. The tests also demonstrated a large number of cells undergoing apoptosis and with nuclear abnormalities related to cell death processes. These results can be explained by the presence of phenolic compounds, saponins, flavonoids and alkaloids, detected in the phytochemical analysis of the extract. Therefore, the extract from L. nobilis in the form generally used by the population does not pose risks related to its genotoxic potential, and also contains components with apoptotic and antigenotoxic potential |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Angiospermas, Bioensayos, Genotoxicidad, Citotoxicidad, Prueba de micronúcleos, Laurus nobilis, Lauraceae |
| Keyword: | Phytochemistry, Angiosperms, Bioassays, Laurus nobilis, Lauraceae, Micronucleus test, Genotoxicity, Cytotoxicity |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
