| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451951 |
| ISSN: | 1984-8250 |
| Authors: | Salva, Emine1 Alan, Saadet2 Karakoyun, Berna3 Çakalağaoğlu, Fulya4 Özbas, Suna5 Akbuğa, Jülide6 |
| Institutions: | 1Inonu University, Faculty of Pharmacy, Malatya. Turquía 2Inonu University, Faculty of Medicine, Malatya. Turquía 3University of Health Sciences, Hamidiye School of Medicine, Estambul. Turquía 4İzmir Ataturk Education and Research Hospital, Department of Medical Pathology, İzmir. Turquía 5Marmara University, Faculty of Pharmacy, Estambul. Turquía 6Medipol University, Faculty of Pharmacy, Estambul. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Granulocyte macrophage colony-stimulating factor (GM-CSF) has been shown to promote the growth, proliferation, and migration of endothelial and keratinocyte cells. Chitosan has been widely used as a biopolymer in wound-healing studies. The aim of this study was to investigate the in vitro proliferative effects of chitosan/pGM-CSF complexes as well as the therapeutic role of the complexes in an in vivo rat wound model. The effect of complexes on cell proliferation and migration was examined. Wounds were made in Wistar-albino rats, and examined histopathologically. The cell proliferation and migration were increased weight ratio- and time-dependently in HaCaT and NIH-3T3 cell lines. Wound healing was significantly accelerated in rats treated with the complexes. These results showed that the delivery of pGM-CSF using chitosan complexes could play an accelerating role in the cell proliferation, migration, and wound-healing process |
| Disciplines: | Medicina |
| Keyword: | Biología celular, Cicatrización, Quitosano, Estimulación celular |
| Keyword: | Cell biology, *, Wound healing, Chitosan, Cell stimulation |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
