| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451758 |
| ISSN: | 1984-8250 |
| Authors: | Santos, Lisia Maria Gobbo dos1 Vicentini, Santos Alves1 Barata Silva, Cristiane1 Fonseca, Mayssa de Andrade1 Magalhães, Carolina Duque1 Carvalho, Virgínia Martins2 Rocha, Ernesto Díaz2 Jacob, Silvana do Couto1 |
| Institutions: | 1Fundacao Instituto Oswaldo Cruz, Instituto Nacional de Controle de Qualidade em Saude, Rio de Janeiro. Brasil 2Universidade Federal do Rio de Janeiro, Faculdade de Farmacia, Rio de Janeiro. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The increasing number of reports of web-based experiences on the success of Cannabis-based therapies in controlling seizures in children suffering from refractory epilepsy have led to efforts by governments and associations to a recent change in legislation. The Brazilian Health Regulatory Agency (ANVISA) allowed the import of Cannabis extracts in 2015 and the registration of the first industrialized drug in 2017. In 2019, ANVISA approved procedures for the granting of a Sanitary Authorization for manufacturing and imports, establishing marketing requirements, prescribing, dispensing, monitoring and surveillance of cannabis products for medicinal purposes. Similar to other consumer products of health concern, is necessary to ensure the quality and health safety of these products worldwide. The aim of the present study to evaluate the presence of As, Cd, Pb, Ni, Cu, Co, Cr and Mn present in Cannabis extracts and resins used in the treatment of pediatric patients with neurological diseases. Samples (48 national and 24 imported) were analyzed by Inductively Coupled Plasma Mass Spectrometry - ICP-MS. The imported extracts presented more homogeneous inorganic element values, while national extracts showed varied levels, thus indicating the highest health risk |
| Disciplines: | Medicina |
| Keyword: | Neurología, Pediatría, Farmacología, Niños, Epilepsia refractaria, Extractos vegetales, Cannabis |
| Keyword: | Neurology, Pediatrics, Pharmacology, Children, Refractory epilepsy, Plant extracts, Cannabis |
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