| Journal: | Brazilian journal of pharmaceutical sciences |
| Database: | PERIÓDICA |
| System number: | 000333590 |
| ISSN: | 1984-8250 |
| Authors: | Santos-Oliveira, Ralph1 |
| Institutions: | 1Instituto de Energia Nuclear, Divisao de Radiofarmacia, Rio de Janeiro. Brasil |
| Year: | 2010 |
| Season: | Jul-Sep |
| Volumen: | 46 |
| Number: | 3 |
| Pages: | 551-554 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | F-18 FDG (2-[18-F] fluoro-2-deoxy-D-glucose) is the most frequently used radiopharmaceutical for PET and PET CT imaging exams. The FDA recently approved the use of the PTSTM (Portable Test System) as an alternative to the standard test proposed by the United States Pharmacopeia using the LAL (Limulus Amebocyte Lysates), that takes longer to perform (about 1h) than the PTSTM (15 min). Recent studies have demonstrated that radiation could interfere with the PTSTM test. In order to study the effects of radiation on the PTSTM test and/or equipment, 27 batches of F-18 FDG produced in the Nuclear Engineering Institute were analyzed. The results showed that no direct correlation with radiation was found in any of the cases |
| Portuguese abstract | O FDG-18 é o radiofármaco mais utilizado nos exames de PET e PET CT. O FDA recentemente aprovou o uso do PTSTM (Portable Test System) como método alternativo ao teste padrão de endotoxina, proposto pela Farmacopéia Americana, considerando que no primeiro há um tempo de espera de 1 hora frente a somente 15 minutos do segundo. Estudo recentes demonstram que a radiação poderia interferir no teste do PTSTM. De modo a avaliar os efeitos da radiação no teste PTSTM foram analisados 27 lotes de F-18 FDG produzidos no Instituto de Engenharia Nuclear. Os resultados demonstraram que em todos os casos nenhuma correlação direta com a radiação foi observada |
| Disciplines: | Química, Medicina |
| Keyword: | Química farmacéutica, Medicina nuclear, Tomografía por emisión de positrones, Radiofármacos, Prueba de endotoxina |
| Keyword: | Chemistry, Medicine, Medicinal chemistry, Nuclear medicine, Positron emission tomography, Radiopharmaceuticals, Endotoxin test |
| Full text: | Texto completo (Ver HTML) |
