| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451262 |
| ISSN: | 1984-8250 |
| Authors: | Ferreira, Magda Rhayanny Assuncao1 Santiago, Rosilene Rodrigues1 Silva Rocha, Walicyranison Plínio1 Souza, Luanda Barbara Ferreira Canário de1 Faria, Maria Graciela Icher2 Mello, Joao Carlos Palazzo de3 Langassner, Silvana Maria Zucolotto1 Chaves, Guilherme Maranhão1 Milan, Eveline Pipolo4 Svidzinski, Terezinha Inez Estivalet2 Soares, Luiz Alberto Lira1 |
| Institutions: | 1Universidade Federal do Rio Grande do Norte, Faculdade de Farmacia, Natal, Rio Grande do Norte. Brasil 2Universidade Estadual de Maringa, Centro de Ciencias Biologicas, Maringa, Parana. Brasil 3Universidade Estadual de Maringa, Centro de Ciencias da Saude, Maringa, Parana. Brasil 4Universidade Federal do Rio Grande do Norte, Centro de Ciencias da Saude, Natal, Rio Grande do Norte. Brasil |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | The aim of this study was evaluate the in vitro antifungal activity of crude extracts from Eugenia uniflora, Libidibia ferrea and Psidium guajava. The extracts were obtained by turbo-extraction using water (AQ) or acetone-water (AC-W) (7:3, v/v) as solvents and lyophilized to obtain the crude extracts (CE). The CE were characterized by UV-Vis, TLC and HPLC. The activity of CEs was investigated against clinical isolates of Candida spp. and the Minimum Inhibitory Concentration (MIC), MIC50 and MIC90 were determinated. The analysis by TLC showed that all CEs presented polyphenols (flavonoids and tannins). The CEs from E. uniflora showed higher amount of polyphenols (30.35 ± 2.15%, AC-W) and the HPLC analysis revealed the tannins in all extracts. The CEs of E. uniflora showed MIC range from 1.9 to 500.0 µg/mL, and lower values of MIC50 and MIC90 against non-albicans Candida isolates. Regarding L. ferrea and P. guajava, the results showing MIC from 3.9 to 1000.0 µg/mL (CE-AQ) against C. albicans. The results demonstrate antifungal performance from CE against various species of Candida spp., suggesting that the herbal species may be use as new potential antifungal agents. Additionally, the polyphenol content can play a pivotal role in the antifungal properties of CE |
| Disciplines: | Biología, Química |
| Keyword: | Fitoquímica, Angiospermas, Plantas medicinales, Polifenoles, Actividad antifúngica, Eugenia uniflora, Psidium guajava, Myrtaceae, Libidibia ferrea, Fabaceae |
| Keyword: | Phytochemistry, Angiosperms, Medicinal plants, Polyphenols, Antifungal activity, Eugenia uniflora, Psidium guajava, Myrtaceae, Libidibia ferrea, Fabaceae |
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