| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452243 |
| ISSN: | 1984-8250 |
| Authors: | Meneses, Richard Rarison Cavalcante1 Damasceno, Nágila Raquel Teixeira2 Cartolano, Flávia De Conti2 Verde, Sara Maria Moreira Lima3 Lira, Letícia Gomes3 Dantas, Mariana Brito1 Viana, Glautemberg de Almeida1 Silva, Mateus Edson da1 Sousa, Ederson Laurindo Holanda de1 Meneses, Gdayllon Cavalcante1 Ferreira, Jamile Magalhães4 Sampaio, Tiago Lima1 Queiroz, Maria Goretti Rodrigues de1 |
| Institutions: | 1Universidade Federal do Ceara, Faculdade de Farmacia, Odontologia e Enfermagem, Fortaleza, Ceara. Brasil 2Universidade de Sao Paulo, Faculdade de Saude Publica, Sao Paulo. Brasil 3Universidade de Fortaleza, Departamento de Nutricao, Fortaleza, Ceara. Brasil 4Universidade Internacional da Integracao da Lusofonia Afro Brasileira, Redencao, Ceara. Brasil |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Analítico, descriptivo |
| English abstract | Hypertriglyceridemia is associated with several metabolic diseases. The triglycerides (TG) disrupt the cholesterol reverse transport and contribute to increased levels of low-density lipoprotein (LDL). High-density lipoprotein (HDL) acts in cholesterol reverse transport as an anti-inflammatory and antioxidant. This study aims to investigate the role of hypertriglyceridemia in the functionality of HDL. Individuals were divided into 4 groups based on high or low HDL-c and triglycerides levels. Biochemical and anthropometric analysis were performed. This study demonstrated that triglycerides promote dysfunctions on HDL, increasing the cardiovascular risk. Blood pressure was higher in subjects with low HDL. Women presented higher levels of HDL-c and low percentage of fat mass. The highest levels of triglycerides were observed in older age. In addition, high levels of triglycerides were associated with higher total cholesterol and LDL-c levels, non-HDL-c, non-esterified fatty acids, and blood glucose, increasing in the ratio of non-HDL-c/HDL-c and ApoB/ApoA-I. The increase of triglycerides levels progressively impairs the antioxidant capacity of HDL, probably due to a higher occurrence of fatty acid peroxidation in individuals with hypertriglyceridemia. Patients with high HDL and low TG levels increased the Lag Time. Furthermore, a positive correlation was found between TG versus HDL particle size, variables that depend on age and anthropometric parameters |
| Disciplines: | Medicina |
| Keyword: | Metabolismo y nutrición, Hipertrigliceridemia, Lipoproteínas, Dislipidemia, Riesgo cardiovascular |
| Keyword: | Metabolism and nutrition, Hypertriglyceridemia, Lipoproteins, Dyslipidemia, Cardiovascular risk |
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