Guidance for nuclear medicine staff on radiopharmaceuticals drug interaction



Document title: Guidance for nuclear medicine staff on radiopharmaceuticals drug interaction
Journal: Brazilian journal of pharmaceutical sciences
Database: PERIÓDICA
System number: 000333726
ISSN: 1984-8250
Authors: 1
Institutions: 1Comissao Nacional de Energia Nuclear, Instituto de Engenharia Nuclear, Rio de Janeiro. Brasil
Year:
Season: Oct-Dic
Volumen: 45
Number: 4
Pages: 619-624
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Numerous drug interactions related to radiopharmaceuticals take place every day in hospitals many of which are not reported or detected. Information concerning this kind of reaction is not abundant, and nuclear medicine staff are usually overwhelmed by this information. To better understand this type of reaction, and to help nuclear medicine staff deal with it, a review of the literature was conducted. The results show that almost all of radiopharmaceuticals marketed around the world present drug interactions with a large variety of compounds. This suggests that a logical framework to make decisions based on reviews incorporating adverse reactions must be created. The review also showed that researchers undertaking a review of literature, or even a systematic review that incorporates drug interactions, must understand the rationale for the suggested methods and be able to implement them in their review. Additionally, a global effort should be made to report as many cases of drug interaction with radiopharmaceuticals as possible. With this, a complete picture of drug interactions with radiopharmaceuticals can be drawn
Portuguese abstract Diversos casos de interações medicamentosas com radiofármacos ocorrem diariamente na rotina hospitalar, contudo muitos deles não são notificados ou mesmo percebidos. Informações a respeito desse tipo de reação não é abundante e os profissionais da medicina nuclear muitas vezes estão assoberbados por essas informações. De modo a entender esse tipo de reação e auxiliar a medicina nuclear a lidar com essa situação uma revisão da literatura foi realizada. Os resultados mostraram que a totalidade dos radiofármacos comercializados no mundo apresentam interação medicamentosa com uma enorme variedade de outros medicamentos. Dessa forma sugere-se que revisões sobre radiofármacos inclua um capítulo sobre efeitos adversos. Além disso, um esforço mundial para notificar efeitos adversos deve ser realizado, pois somente dessa forma se terá um quadro real da situação referente interações medicamentosas com radiofármacos
Disciplines: Química,
Medicina
Keyword: Química farmacéutica,
Medicina nuclear,
Radiofármacos,
Radiología,
Interacción medicamentosa
Keyword: Chemistry,
Medicine,
Medicinal chemistry,
Nuclear medicine,
Radiopharmaceuticals,
Radiology,
Drug interaction
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