| Journal: | Brazilian journal of pharmaceutical sciences |
| Database: | PERIÓDICA |
| System number: | 000359912 |
| ISSN: | 1984-8250 |
| Authors: | Queiroz, Fernando Marlisson de1 Matias, Kayo Wanderson de Oliveira1 Cunha, Mylena Mylana Freire da1 Schwarz, Aline1 |
| Institutions: | 1Universidade Federal do Rio Grande do Norte, Departamento de Analises Clinicas e Toxicologicas, Natal, Rio Grande do Norte. Brasil |
| Year: | 2013 |
| Season: | Ene-Mar |
| Volumen: | 49 |
| Number: | 1 |
| Pages: | 135-148 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental |
| English abstract | Phyllanthus niruri L. (Euphorbiaceae), known as "quebra-pedra" (Portuguese for "stonebreaker"), is an herb used for kidney disorders. In light of its frequent use by the population, the present study aimed to investigate the genotoxic, antigenotoxic and cytotoxic activities of a standardized P. niruri extract in bone marrow rats. Three groups of 12 animals were treated daily by gavage over a period of 30 days, with 50, 150 or 250 mg/kg of P. niruri extract aqueous solution. The control group (n = 12) received tap water. At the end of treatment (day 31), groups were divided into two minor subgroups (n=6/group) and received cyclophosphamide (50 mg/kg, i.p.) or saline 0.9% (i.p.). After 24 hours, we evaluated the frequency of micronucleated polychromatic erythrocytes for each animal (MNPCE) at 1000 PCE. Cytotoxicity was evaluated with the PCE/NCE ratio (NEC = normochromatic erythrocytes). General toxicity was assessed during treatment using the parameters of body weight gain, ration and water consumption. The dry extract did not provoke changes in body weight, weight gain, ration and water intake or changes in the frequency of MNPCE or cytotoxicity in bone marrow. We propose that the P. niruri extract used here showed no genotoxic, antigenotoxic and cytotoxic activities under the experimental conditions |
| Portuguese abstract | Phyllanthus niruri L. (Euphorbiaceae), conhecida como "quebra-pedra", é uma planta medicinal utilizada frequentemente pela população no tratamento de problemas renais. Foram avaliadas as atividades genotóxicas, antigenotóxicas e citotóxicas de um extrato padronizado dessa espécie em ratos. Três grupos de doze animais foram tratados durante trinta dias, por gavagem, com 50, 150 ou 250 mg/kg/dia de solução aquosa do extrato de P. niruri e um grupo controle (n=12) recebeu água destilada pela mesma via. No final do tratamento os grupos foram divididos em dois subgrupos (6 animais/grupo) e receberam uma .. |
| Disciplines: | Biología, Química, Medicina |
| Keyword: | Genética, Fitoquímica, Toxicología, Phyllanthus niruri, Genotoxicidad, Análisis toxicológico, Estudio experimental, Plantas medicinales, Evaluación |
| Keyword: | Biology, Chemistry, Medicine, Genetics, Phytochemistry, Toxicology, Phyllanthus niruri, Genotoxicity, Toxicological analysis, Experimental study, Medicinal plants, Evaluation |
| Full text: | Texto completo (Ver PDF) |
