Ethnopharmacological activity of Hedera nepalensis K. Koch extracts and lupeol against alloxan-induced type I diabetes
Document title: Ethnopharmacological activity of Hedera nepalensis K. Koch extracts and lupeol against alloxan-induced type I diabetes
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451295
ISSN: 1984-8250
Authors: 1
2
1
1
Institutions: 1Quaid-i-Azam University, Faculty of Biological Sciences, Islamabad. Pakistán
2University of Gujrat, Department of Biochemistry and Biotechnology,, Gujrat. Pakistán
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract In this study, we investigated the protective effects of Hedera nepalensis crude extract, its fractions and lupeol in alloxan-induced diabetic rats. Lupeol and n-hexane (HNN) fraction significantly reduced the blood glucose level by increasing insulin level in time dependent manner, and also significantly increased amylase and lipase activity in diabetic rats. Elevated levels of alanine transaminases (ALT), aspartate transaminases (AST), thiobarbituric acid reactive substances (TBARS), nitrite, hydrogen peroxide (H2O2), total bilirubin and total protein in blood serum were efficiently restored to normal levels. Suppressed enzymatic activity of catalase (CAT), superoxide dismutase (SOD), reduced glutathione (GSH) and peroxidase (POD) were also restored to their normal levels. Kidney functions were also restored to normal level after treatment with HNN and lupeol. HNN fraction and lupeol of H. nepalensis prevented oxidative stress in alloxan-induced diabetic rats. This study signifies the importance of H. nepalensis and lupeol in ameliorating diabetes by inducing insulin secretion in diabetic model rats
Disciplines: Química,
Medicina
Keyword: Farmacología,
Endocrinología,
Plantas medicinales,
Etnofarmacología,
Antioxidantes,
Amilasas,
Diabetes mellitus,
Insulina,
Lupeol,
Hedera nepalensis,
Araliaceae
Keyword: Pharmacology,
Endocrinology,
Medicinal plants,
Ethnopharmacology,
Antioxidants,
Amylases,
Diabetes mellitus,
Insulin,
Lupeol,
Hedera nepalensis,
Araliaceae
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