| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451486 |
| ISSN: | 1984-8250 |
| Authors: | Medeiros, Tessio David de1 Pereira, Annyelly Tavares2 Silva, Flavio Santos da3 Bortolin, Raul Hernandes2 Taveira, Karinna Veríssimo Meira1 Abreu, Bento João da Graça Azevedo1 Rezende, Adriana Augusto de2 Farias, Naisandra Bezerra da Silva1 Barbosa, José Maria4 Medeiros, Karina Carla de Paula1 |
| Institutions: | 1Universidade Federal do Rio Grande do Norte, Centro de Biociencias, Natal, Rio Grande do Norte. Brasil 2Universidade Federal do Rio Grande do Norte, Departamento de Analisis Clinicos e Toxicologicos, Natal, Rio Grande do Norte. Brasil 3Universidade Federal Rural do Semi-Arido, Departamento de Ciencias da Saude, Mossoro, Rio Grande do Norte. Brasil 4Universidade Federal da Paraiba, Laboratorio de Tecnologia Farmaceutica, Joao Pessoa, Paraiba. Brasil |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Diabetes Mellitus (DM) is a metabolic syndrome characterized by hyperglycemia. Chronic complications affect a number of organs, including the lungs. Cissampelos sympodialis Eichl (Menispermaceae) is a plant used to treat respiratory diseases. The aim of this study was to evaluate the effect of Cissampelos sympodialis extract (CSE) in lungs of diabetic rats. We used 30 Wistar rats divided into three groups: control group (CG), diabetic group (DG) and diabetic Cissampelos sympodialis treatment group (DTG). Diabetes was induced by streptozotocin (40 mg/kg i.v.). The CSE (400 mg/kg, po) was administered daily, during four weeks, beginning one week after the onset of DM. The treatment with CSE was not able to reduce blood glucose levels after streptozotocin injection. However, it was able to decrease cholesterol and triglycerides and prevent damage on pancreatic islets morphology. Additionally, morphological alterations such as alveolar septa loss, inflammatory infiltrate and fibrosis were seen in lung tissue of rats with DM, and treatment with CSE apparently reversed these histopathological findings. Thus, CSE treatment reduced the lipid profile and restored the lung architecture of diabetic animals by a mechanism independent of glycemia and which might be associated with the reduction of the damage on the pancreatic islets |
| Disciplines: | Química, Medicina |
| Keyword: | Fitoquímica, Farmacología, Medicina experimental, Diabetes, Daño tisular, Pulmones, Extractos vegetales, Cissampelos sympodialis, Menispermaceae |
| Keyword: | Phytochemistry, Pharmacology, Experimental medicine, Diabetes, Tissue damage, Lungs, Plant extracts, Cissampelos sympodialis, Menispermaceae |
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