Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil
Document title: Estimated glomerular filtration rate and drug dose adjustment in patients in an intensive care unit in Brazil
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451297
ISSN: 1984-8250
Authors: 1
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Institutions: 1Universidade Federal da Bahia, Instituto Multidisciplinar em Saude, Salvador, Bahia. Brasil
2Universidade Federal da Bahia, Programa de Pos-graduacao em Medicina e Saude, Salvador, Bahia. Brasil
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Objectives. This study sought to compare the estimated glomerular filtration rate and the indication of dose adjustment of antimicrobials when using Cockcroft-Gault or Modification of Diet in Renal Disease. Methods. A cross-sectional study was performed with patients admitted to the intensive care unit of a Brazilian general hospital. The glomerular filtration rate was calculated for patients on all days using the Cockcroft-Gault and Modification of Diet in Renal Disease equations. The difference in estimated glomerular filtration and the dose adjustment indication of antimicrobials were assessed. Results. A total of 631 patients were included in this study. The median estimated glomerular filtration was significantly higher when estimated using Modification of Diet in Renal Disease (100.3 mL/ min/1.73 m2) than the estimation by Cockcroft-Gault (83.2 mL/min) [p<0.001]. Greater differences in estimations produced by the two formulae were observed in patients at extremes of weight and age, and a different dose adjustment was indicated for all antimicrobials assessed. Conclusions. These results demonstrate a significant difference in estimated glomerular filtration rate values when calculated using either Cockcroft-Gault or Modification of Diet in Renal Disease as well as in the indication of dose adjustment in an intensive care unit
Disciplines: Medicina
Keyword: Farmacología,
Nefrología,
Antimicrobianos,
Tasa de filtración glomerular,
Insuficiencia renal
Keyword: Pharmacology,
Nephrology,
Antimicrobial agents,
Glomerular filtration rate,
Renal insufficiency
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