| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451329 |
| ISSN: | 1984-8250 |
| Authors: | Saleem, Afia1 Bukhari, Syed Majid1 Zaidi, Asma1 Farooq, Umar1 Ali, Majid1 Khan, Asma2 Khan, Sidra3 Shah, Kausar Hussain4 Mahmood, Adeem5 Khan, Farhan Ahmed1 |
| Institutions: | 1COMSATS University Islamabad, Department of Chemistry, Abbottabad. Pakistán 2Chinese Academy of Science, Fujian Institute of Research on Structure of Matter, Fuzhou, Fujian. China 3Schanghai Jiao Tong University, School of Chemistry and Chemical Engineering, Shanghai. China 4Bahauddin Zakariya University, Institute of Pure and Applied Biology, Multan, Punjab. Pakistán 5King Saud University, College of Science, Riyadh. Arabia Saudita |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The 4-Hydroxycoumarin derivatives are known to show a broad spectrum of pharmacological applications. In this paper we are reporting the synthesis of a new series of 4-Hydroxycoumarin derivatives synthesized through Knovenegal condensation; they were characterized by using UV-Vis, FT-IR, NMR spectroscopies. The synthesized compounds were evaluated for antibacterial activity against Staphylococcus aureus and Salmonella typhimurium strains. The compounds (2), (3) and (8) showed favorable antibacterial activity with zone of inhibitions 26.5± 0.84, 26.0 ± 0.56 and 26.0 ± 0.26 against Staphylococcus aureus (Gram-positive) respectively. However, the compounds (5) and (9) were found more active with 19.5 ± 0.59 and 19.5 ± 0.32 zone of inhibitions against Salmonella typhimurium (Gram-negative). Whereas, in urease inhibition assay, none of the synthesized derivatives showed significant anti-urease activity; although, in carbonic anhydrase-II inhibition assay, the compound (2) and (6) showed enzyme inhibition activity with IC50 values 263±0.3 and 456±0.1, respectively |
| Disciplines: | Medicina, Química |
| Keyword: | Farmacología, Química farmacéutica, Síntesis química, Derivados sinteticos, Hidroxicumarinas, Antibacterianos, Inhibición enzimática, Anhidrasa carbónica, Aldehídos |
| Keyword: | Pharmacology, Medicinal chemistry, Chemical synthesis, Hydroxycoumarins, Antibacterial agents, Enzymatic inhibition, Carbonic anhydrase, Aldehydes |
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