Revista: | Brazilian Journal of Pharmaceutical Sciences |
Base de datos: | PERIÓDICA |
Número de sistema: | 000452103 |
ISSN: | 1984-8250 |
Autores: | Xu, Tingting1 Wang, Xiumei1 He, Zhongwei2 Yang, Li1 Wei, Rongrui1 Zhong, Guoyue1 He, Junwei1 |
Instituciones: | 1Jiangxi University of Chinese Medicine, Nanchang, Jiangxi. China 2Jiangxi University of Finance and Economics, School of Information Technology, Nanchang, Jiangxi. China |
Año: | 2022 |
Volumen: | 58 |
País: | Brasil |
Idioma: | Inglés |
Tipo de documento: | Artículo |
Enfoque: | Experimental, aplicado |
Resumen en inglés | Lagopsis supina (Steph) IK. Gal. was a traditional Chinese medicinal plant for promoting blood circulation and removing blood stasis (PBCRBS), anti-inflammatory and diuresis with little scientific validation. The aims of this study were first to evaluate the PBCRBS and anti-inflammatory effects of L. supina in a rat model of traumatic blood stasis (TBS). We demonstrated that an ethanolic extract of L. supina (LS, 460 mg/kg/d) possessed significant PBCRBS and remarkable inhibitory effect on inflammation cytokines, which were associated with renovated amount of the injured muscle fibers, alleviate the degree of the damaged tissue edema, decreased the number of inflammatory cells, increased the number of the capillary hyperplasia by hematoxylin and eosin (HE), as well as remarkably down-regulated ( p < 0.05 or p < 0.01) the levels of inflammation cytokines, including TNF-α, IL-6, IL-8, and IL-10 by ELISA. This finding provide a pharmacological basis and partial interpretation for the clinical application of L. supina, which has therapeutic properties for blood stasis syndrome (BSS) and inflammation-related diseases |
Disciplinas: | Química |
Palabras clave: | Farmacología, Hematología, Plantas medicinales, Estasis sanguínea, Actividad antiinflamatoria, Lagopsis supina, Lamiaceae |
Keyword: | Pharmacology, Hematology, Medicinal plants, Blood stasis, Anti-inflammatory activity, Lagopsis supina, Lamiaceae |
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