| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451833 |
| ISSN: | 1984-8250 |
| Authors: | Duan, Hanzhong1 Xia, Li2 Lan, Qing3 |
| Institutions: | 1Zhejiang Chinese Medical University, Hangzhou TCM Hospital Affiliated , Hangzhou, Zhejiang. China 2Zhejiang Xiaoshan Hospital, Department of Otolaryngology, Xiaoshan, Zhejiang. China 3Soochow University, The Second Affiliated Hospital, Suzhou, Jiangsu. China |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Aplicado, descriptivo |
| English abstract | This study investigated the efficacy and safety of fluticasone propionate nasal spray in treatment of adenoidal hypertrophic snoring in children. Fifty-six children with adenoidal hypertrophic snoring were enrolled. According to adenoidal-nasopharyngeal ratio (ANR) in lateral nasal X-ray examination,the children were assigned in moderategroup (23 cases) and severegroup (33 cases).The fluticasone propionate nasal spray was used for all patientsfor 4 weeks.In 56 patients, after treatment, compared with before treatment, the snoring, sleep apneaand nasal obstruction scores in moderategroupand the nasal obstruction score in severegroupwere significantly decreased,respectively (P < 0.05).The decreases of snoring, sleep apnea, mouth breathing and nasal obstruction scores after treatment in moderate group were significantly higher than those in severe group, respectively (P <0.001).After treatment, in 18 patients with ateral nasal X-ray examination,the adenoid size was obviously reduced, and the nasopharynx airway was obviously enlarged. The meanANRdropped from 0.76±0.10 to 0.72±0.09(P <0.001).Duringtreatment, only 2 of 56 patients were reported with intranasal dryness and occasional epistaxis, which were self-healed without treatment.Fluticasone propionate nasal spray is effective and safe for treatment of children’s snoring caused by adenoidal hypertrophy |
| Disciplines: | Medicina |
| Keyword: | Farmacología, Otorrinolaringología, Pediatría, Hipertrofia adenoidea, Ronquido, Propionato de fluticasona |
| Keyword: | Pharmacology, Otolaryngology, Pediatrics, Adenoid hypertrophy, Snoring, Fluticasone propionate |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
