Effect on hyperglycemia and pancreas cells of chaya aqueous extracts from two different regions in streptozotocin-induced diabetes rats
Document title: Effect on hyperglycemia and pancreas cells of chaya aqueous extracts from two different regions in streptozotocin-induced diabetes rats
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451254
ISSN: 1984-8250
Authors: 1
1
1
2
1
1
Institutions: 1Universidad Juárez del Estado de Durango, Facultad de Ciencias Químicas, Durango. México
2Universidad Juárez del Estado de Durango, Instituto de Investigaciones Científicas, Durango. México
Year:
Volumen: 56
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Cnidoscolus chayamansa is a native plant of the Mayan region, which is also cultivated in other places like northern Mexico, Tunisia and India. Many properties are attributed to Mayan Chaya, such as aid in the control of glycemia in diabetics. Thus this study aimed to evaluate the hypoglycemic effects of chaya aqueous extracts in a model of streptozotisin-induced diabetic Wistar rats. Chaya aqueous extracts were collected from plants cultivated in Quinta Roo (Mayan region) and Durango (northern Mexico), and in this study we compare their effect with metformin (as a control). Additionally, we compared the extracts mass profiles from both regions by high-resolution liquid chromatography coupled to a triple quadrupole tandem mass detector (HPLC-MS/MS QQQ). Finally, a study of the pancreatic tissue was carried out to evaluate the effects of the extracts on the Langerhans islets. Both extracts showed a good hypoglycemic effect after two weeks of treatment, and the Langerhans islets showed a partial recovery due to the effect of the treatment. Although the plants were cultivated at a distance of 2,350 km and under different weather, the compounds found in both did not show significant differences
Disciplines: Química,
Medicina
Keyword: Farmacología,
Medicina experimental,
Diabetes,
Hipoglucemiantes,
Extractos vegetales,
Cnidoscolus chayamansa,
Euphorbiaceae
Keyword: Pharmacology,
Experimental medicine,
Diabetes,
Hypoglycemic agents,
Plant extracts,
Cnidoscolus chayamansa,
Euphorbiaceae
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