| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451328 |
| ISSN: | 1984-8250 |
| Authors: | Nwachukwu, Nkemakolam1 Ofoefule, Sabinus Ifeanyi2 |
| Institutions: | 1University of Port Harcourt, Department of Pharmaceutics and Pharmaceutical Technology, Port Harcourt, Rivers. Nigeria 2University of Nigeria, Faculty of Pharmaceutical Sciences, Nsukka, Enugu State. Nigeria |
| Year: | 2020 |
| Volumen: | 56 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The effect of drying method, a process variable, on the powder and compaction properties of microcrystalline cellulose (MCC) obtained from the partial acid hydrolysis of bleached alpha (α) cellulose content of matured linters of Gossypium herbaceum (GH) was investigated. A portion of the wet MCC obtained was fluid bed dried at 60 ± 1 ºC, inlet air of 30 m3 min-1 for 3 h (coded MCC-GossF). The second portion was lyophilized at - 45 ± 2 ºC for 6 h (coded MCC-GossL). The physicochemical, scanning electron micrographs, X ray diffraction patterns and micromeritic properties of the derived MCCs were determined using standard methods. The cohesiveness and compactibility of the powders were investigated using Kawakita model while the deformation and compressibility pattern were determined using Heckel model. Avicel® PH 102 (AV-102) was used as comparing standard. Ash values of < 2%, pH (6.54 ± 0.23 to 6.58 ± 0.08), degree of polymerization, DP (231.50) was obtained. MCC-GossF had higher moisture content, swellability, better flow indices, and lesser porosity than MCC-GossL. Kawakita model demonstrated good consolidation and compactibility for both powders. Compacts of MCC-GossL were significantly (p < 0.05) harder than those of MCC-GossF. Heckel analysis demonstrated good compressibility and deformation pattern that was comparable with AV-102. Compacts of MCC-GossL had better mechanical and tablet compression properties than MCC-GossF. Method of drying significantly (p < 0.05) affected the powder and compaction properties of GH MCC |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Excipientes, Celulosa microcristalina, Métodos de secado, Gossypium herbaceum, Malvaceae |
| Keyword: | Medicinal chemistry, Excipients, Gossypium herbaceum, Drying methods, Microcrystalline cellulose |
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