| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000450966 |
| ISSN: | 1984-8250 |
| Authors: | Dhillon, Pallavi1 Mirza, Mohd. Aamir1 Anwer, Md. Khalid2 Alshetaili, Abdullah Saud2 Alshahrani, Saad Maria2 Iqbal, Zeenat1 |
| Institutions: | 1Jamia Hamdard University, Department of Pharmaceutics, Nueva Delhi, Delhi. India 2Prince Sattam Bin Abdulaziz University, College of Pharmacy, Al-kharj. Arabia Saudita |
| Year: | 2019 |
| Volumen: | 55 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The foremost aim of the current research was to prolong and sustain the release of erythromycin (ERY) by preparing a solid lipid nanoparticles (SLNs)-based gel formulation for the safe and effective treatment of acne. ERY-loaded SLNs were developed, and various process variables were optimized with respect to particle size, zeta potential, and entrapment efficiency using the Taguchi model. The average particle size, PDI, zeta potential, drug entrapment efficiency, and drug loading of optimized SLN (F4) were found to be 176.2±1.82 nm, 0.275±0.011, -34.0±0.84, 73.56%, and 69.74% respectively. The optimized SLN (F4) was successfully incorporated into the carbopol-based hydrogel. The in vitro release of ERY from the SLN gel and plain gel were compared and found to be 90.94% and 87.94% respectively. In vitro study of ERY-loaded SLN gel showed sustained delivery of drug from formulation thus enhancing the antimicrobial activity after 30 hours when compared to ERY plain gel |
| Disciplines: | Química |
| Keyword: | Química farmacéutica, Eritromicina, Sistemas de liberación de fármacos, Nanopartículas lípidas sólidas, Nanogeles, Modelo de Taguchi, Discos de difusión |
| Keyword: | Medicinal chemistry, Erythromycin, Drug delivery systems, Solid lipid nanoparticles, Nanogels, Taguchi model, Diffusion discs |
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