| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451860 |
| ISSN: | 1984-8250 |
| Authors: | Abbaspour, Mohammadreza1 Hoseini, Hoda2 Sobhani, Zahra2 Emami, Seyed Ahmad2 Bazzaz, Bibi Sedigheh Fazly1 Javadi, Behjat2 |
| Institutions: | 1Mashhad University of Medical Sciences, Pharmaceutical Technology Institute, Mashhad. Irán 2Mashhad University of Medical Sciences, School of Pharmacy, Mashhad. Irán |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Intrauterine adhesions cause several gynecological problems. Althaea officinalis L. roots known as marshmallows contain polysaccharides (M.P.) which possess anti-inflammatory and anti-ulcerogenic activities also can form a bio-adhesive layer on damaged epithelial membranes prompting healing processes. Vaginal formulations of herbal origin are commonly applied to relieve cervico-uterine inflammation. Herein, we aim to develop and evaluate vaginal suppositories containing polysaccharides isolated from the A. officinalis root. Six formulations (four P.E.G.-based and two lipid-based suppositories containing 25% and 50% M.P.) met standard requirements, which were then subjected to qualitative and quantitative evaluation. All suppositories exhibited acceptable weights, hardness, content uniformity, melting point, and disintegration time, which fall within the acceptable recommended limits. Higher concentrations of M.P. in PEG-bases moderately increased the hardness (p<0.05). PEG-formulations showed content uniformity>90% of the average content while it was 75-83% for suppocire formulations. All formulations disintegrated in<30minutes. In-vitro release test revealed that M.P. release from 25%-MP formulations was higher than that of 50%-M.P. suppositories. Overall, results revealed the feasibility of preparing P.E.G.-or lipid-based suppositories containing M.P., which met the B.P. quality requirement |
| Disciplines: | Medicina |
| Keyword: | Ginecología y obstetricia, Farmacología, Adhesión intrauterina, Plantas medicinales, Polisacáridos, Supositorio vaginal, Althaea officinalis, Malvaceae |
| Keyword: | Gynecology and obstetrics, Pharmacology, Intrauterine adhesion, Medicinal plants, Polysaccharides, Vaginal suppository, Althaea officinalis, Malvaceae |
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