| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452177 |
| ISSN: | 1984-8250 |
| Authors: | Hasan, Nadeem1 Nayak, Amit Kumar2 Sanaullah, Syed1 Sami, Farheen3 Majeed, Shahnaz3 Badgujar, Vishal Bhagwan3 Hasnain, Saquib4 Ansari, Mohammed Tahir3 |
| Institutions: | 1Luqman College of Pharmacy, Department of Pharmaceutics, Gulbarga, Karnataka. India 2Seemanta Institute of Pharmaceutical Sciences, Department of Pharmaceutics, Mayurbhanj, Orissa. India 3Universiti Kuala Lumpur, Royal College of Medicine, Ipoh, Perak. Malasia 4Shri Venkateshwara University, Department of Pharmacy, Amroha, Uttar Pradesh. India |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Periodontitis is an oral disease associated with inflammation and pain with swollen and bleeding gums. In the present study, dental pastes containing NSAIDs, namely, diclofenac sodium and nimesulide (1 % w/w) were prepared to treat periodontitis. Dental pastes of diclofenac sodium and nimesulide (1 % w/w) were prepared with/without mucoadhesive hydrocolloid polymers such as sodium carboxy methyl cellulose (NaCMC), hydroxyl ethyl cellulose (HEC) and methyl cellulose (MC) by conventional trituration method. The pH, drug content, viscosity, tube spreadability and tube extrudability of these prepared dental pastes were measured. These dental pastes of diclofenac sodium and nimesulide (1 % w/w) were characterized by FTIR analyses for drug-excipient compatibility. The in vitro drug releases from these dental pastes in 6.4 pH phosphate buffer solution displayed sustained release over longer period and the drug release rate was found to be decreased when the concentration of mucoadhesive polymer was increased. These dental pastes displayed good adhesion to the oral mucosa revealing more retention time in mouth when tested for ex vivo mucoadhesion using bovine cheek pouch. The stability study results reveal that the DC3 and NC3 dental paste formulations were found stable enough over a longer period in different storage conditions. The present study revealed that the prepared mucoadhesive dental pastes of diclofenac sodium and nimesulide (1 % w/w) had good adhesion with the oral mucosa to maintain consistent release of drugs over prolonged time |
| Disciplines: | Medicina, Química |
| Keyword: | Química farmacéutica, Odontología, Periodontitis, Pasta dental, Nimesulida, Diclofenaco, Mucoadhesivos |
| Keyword: | Medicinal chemistry, Dentistry, Periodontitis, Toothpaste, Nimesulide, Diclofenac, Mucoadhesives |
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