Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat
Document title: Comparative assessment of effect of malt with different bud length on prolactin in hyperprolactinemia rat
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000451525
ISSN: 1984-8250
Authors: 1
2
1
3
1
1
1
1
Institutions: 1The Third Hospital of Wuhan, Wuhan, Hubei. China
2Xin Jiang Medical University, College of Pharmacy, Urumqi, Xinjiang. China
3Wuhan JinYinTan Hospital, Department of Pharmacy, Wuhan, Hubei. China
Year:
Volumen: 57
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Malt is the mature fruit of Hordeum vulgare L. after germination and drying and has been applied for treatment female abnormal galactorrhea. Previous studies have showed total alkaloids in malt have anti-HPRL effect. However, total alkaloids of malt change with the growth cycle, and the specified levels of total alkaloids in different bud length of malt have not been decided. To determine the definitive level of total alkaloids in different buds of malt and the most suitable bud length for clinical application by comparing effects on hyperprolactinemia rat. During the budding of malt, the content of total alkaloids first increased and then decreased, and it peaked at a bud length of 0.75 cm. Treated the HPRL model rats with different buds of malt, the PRL level was decreased, the number of PRLpositive cells and the mRNA expression level in the pituitary were significantly declined, and the number of dopamine D1 and D2 receptors in the hypothalamus was increased. The above changes were most significant in 0.75 cm bud. These results suggest that in terms of the content of effective substance and the effects on HPRL model rats, a malt bud length of 0.75 cm is optimal for clinical application
Disciplines: Química,
Medicina
Keyword: Endocrinología,
Farmacología,
Medicina experimental,
Galactorrea,
Receptores de dopamina,
Malta,
Alcaloides,
Sistema endócrino,
Ratas
Keyword: Endocrinology,
Pharmacology,
Experimental medicine,
Galactorrhea,
Dopamine receptors,
Malt,
Alkaloids,
Endocrine system,
Rats
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