| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451512 |
| ISSN: | 1984-8250 |
| Authors: | Soprani, Letícia Carlesso1 Andrade, Jean P. de1 Santos, Vanessa Dias dos2 Alves Araújo, Anderson3 Bastida, Jaume4 Silva, Cristian A. Gasca5 Silveira, Damaris5 Borges, Warley de Souza2 Jamal, Claudia Masrouah1 |
| Institutions: | 1Universidade Federal do Espirito Santo, Departamento de Ciencias Farmaceuticas, Vitoria, Espirito Santo. Brasil 2Universidade Federal do Espirito Santo, Departamento de Química, Vitoria, Espirito Santo. Brasil 3Universidade Federal do Espirito Santo, Departamento de Botanica, Sao Mateus, Espirito Santo. Brasil 4Universidad de Barcelona, Facultad de Farmacia, Barcelona. España 5Universidade de Brasilia, Faculdade de Ciencias da Saude, Brasilia, Distrito Federal. Brasil |
| Year: | 2021 |
| Volumen: | 57 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | Hippeastrum puniceum is a species that belongs to the Amaryllidaceae family. A particular characteristic of this family is the consistent and very specific presence of isoquinoline alkaloids, which have demonstrated a wide range of biological activities such as antioxidant, antiviral, antifungal, antiparasitic, and acetylcholinesterase inhibitory activity, among others. In the present work, fifteen alkaloids were identified from the bulbs of Hippeastrum puniceum (Lam.) Kuntz using a GC-MS approach. The alkaloids 9-O-demethyllycoramine, 9-demethyl-2α-hydroxyhomolycorine, lycorine and tazettine were isolated through chromatographic techniques. The typical Amaryllidaceae alkaloids lycorine and tazettine, along with the crude and ethyl acetate extract from bulbs of the species were evaluated for their inhibitory potential on α-amylase, α-glucosidase, tyrosinase and acetylcholinesterase activity. Although no significant inhibition activity was observed against α-amylase, α-glucosidase and tyrosinase from the tested samples, the crude and ethyl acetate extracts showed remarkable acetylcholinesterase inhibitory activity. The biological activity results that correlated to the alkaloid chemical profile by GC-MS are discussed herein. Therefore, this study contributed to the knowledge of the chemical and biological properties of Hippeastrum puniceum (Lam.) and can subsidize future studies of this species |
| Disciplines: | Química |
| Keyword: | Fitoquímica, Farmacología, Alcaloides isoquinolínicos, Inhibición enzimática, Acetilcolinesterasa, Hippeastrum puniceum, Amaryllidaceae |
| Keyword: | Phytochemistry, Pharmacology, Isoquinoline alkaloids, Enzymatic inhibition, Acetylcholinesterase, Hippeastrum puniceum, Amaryllidaceae |
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