| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451565 |
| ISSN: | 1984-8250 |
| Authors: | Ribeiro, Jane Cristina Lara1 Bruginski, Estevan1 Zuccolotto, Tatiana1 Santos, Alan Diego da Conceição2 Bomfim, Larissa Mendes3 Rocha, Suellen Laila Andrade3 Barison, Andersson2 Sassaki, Guilherme2 Cavalcanti, Sócrates Cabral de Holanda4 Costa, Emmanoel Vilaça5 Soares, Milena Botelho Pereira3 Bezerra, Daniel Pereira3 Campos, Francinete Ramos1 |
| Institutions: | 1Universidade Federal do Parana, Departamento de Farmacia, Curitiba, Parana. Brasil 2Universidade Federal do Parana, Centro NMR, Curitiba, Parana. Brasil 3Fundacao Oswaldo Cruz, Centro de Pesquisa Goncalo Moniz, Salvador, Bahia. Brasil 4Universidade Federal de Sergipe, Departamento de Farmacia, Aracaju, Sergipe. Brasil 5Universidade Federal do Amazonas, Departamento de Quimica, Manaus. Amazonas. Brasil |
| Year: | 2021 |
| Volumen: | 57 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The seed oil of Annona salzmannii A. DC. was analyzed by GC-MS and 1H qNMR, revealing a mixture of unsaturated (80.5%) and saturated (18.7%) fatty acids. Linoleic (45.3%) and oleic (33.5%) acid were the major unsaturated fatty acids identified, while palmitic acid (14.3%) was the major saturated fatty acid. The larvicidal effects of A. salzmannii seed oil were evaluated against third-instar larvae of Aedes aegypti (Linn.). The oil exhibited moderate larvicidal activity, with a LC50 of 569.77 ppm (95% CI = 408.11 to 825.88 ppm). However, when the cytotoxic effects of the oil were evaluated, no expressive antiproliferative effects were observed in tumor cell lines B16-F10 (mouse melanoma), HepG2 (human hepatocellular carcinoma), K562 (human chronic myelocytic leukemia), HL-60 (human promyelocytic leukemia), and non-tumor cell line PBMC (peripheral blood mononuclear cells), with IC50 values > 50 μg·mL-1. This is the first study to evaluate the chemical composition, larvicidal and cytotoxic activity of A. salzmannii seed oil |
| Disciplines: | Química, Biología |
| Keyword: | Fitoquímica, Farmacología, Semillas, Aceites vegetales, Composición química, Actividad larvicida, Actividad citotóxica, Annona salzmannii, Annonaceae |
| Keyword: | Phytochemistry, Pharmacology, Seeds, Plant oils, Chemical composition, Larvicidal activity, Cytotoxic activity, Annona salzmannii, Annonaceae |
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