| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000451062 |
| ISSN: | 1984-8250 |
| Authors: | Kauffmann, Carla1 Giacomin, Ana Caroline1 Arossi, Kelen1 Pacheco, Leandra Andressa1 Hoehne, Lucélia2 Freitas, Elisete Maria de1 Machado, Gérzia Maria de Carvalho3 Cavalheiro, Marilene Marcuzzo do Canto3 Gnoatto, Simone Cristina Baggio4 Ethur, Eduardo Miranda2 |
| Institutions: | 1Universidade do Vale do Taquari, Centro de Ciencias Biologicas e da Saude, Lajeado, Rio Grande do Sul. Brasil 2Universidade do Vale do Taquari, Centro de Ciencias Exatas e Tecnologicas, Lajeado, Rio Grande do Sul. Brasil 3Fundacao Oswaldo Cruz, Laboratorio de Bioquimica de Trypanosomatideos, Rio de Janeiro. Brasil 4Universidade Federal do Rio Grande do Sul, Faculdade de Farmacia, Porto Alegre, Rio Grande do Sul. Brasil |
| Year: | 2019 |
| Volumen: | 55 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | In South American folk medicine members of the genus Myrciaria are used for the treatment of malaria, diarrhoea, asthma, inflammation and post-partum uterine cleansing. The aim of this work was to evaluate its antileishmanial properties (in vitro) of essential oil derived from leaves of Myrciaria plinioides D. Legrand, a plant species that is native in South of Brazil. The essential oil was obtained by hydro-distillation using fresh leaves of M. plinioides. The chemical composition of this essential oil (MPEO, M. plinioides essential oil) was determined by gas chromatography coupled to mass spectrometry (GC-MS). MPEO was assayed in vitro for antileishmanial properties against promastigotes of Leishmania amazonensis and Leishmania infantum, and for cytotoxicity against murine peritoneal macrophages. The MPEO comprised 66 components and was rich in oxygenated sesquiterpenes (82.66%) containing spathulenol (21.12%) as its major constituent. The MPEO was effective against L. amazonensis with IC50 value of 14.16 ± 7.40 µg/mL, while against L. infantum the IC50 value was higher with 101.50 ± 5.78 µg/mL. The MPEO showed significant activity against L. amazonensis, and presented a selectivity index (SI) of 6.60. The results suggest that the essential oil from leaves of M. plinioides is a promising source for new antileishmanial agents against L. amazonensis |
| Disciplines: | Química, Medicina |
| Keyword: | Fitoquímica, Farmacología, Parasitología, Aceites esenciales, Actividad antiparasitaria, Myrciaria plinioides, Myrtaceae, Leishmania amazonensis, Leishmania infantum |
| Keyword: | Phytochemistry, Pharmacology, Parasitology, Essential oils, Antiparasitic activity, Myrciaria plinioides, Myrtaceae, Leishmania amazonensis, Leishmania infantum |
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