Alleviation of neuropathic pain by trazodone in rats
Document title: Alleviation of neuropathic pain by trazodone in rats
Journal: Brazilian Journal of Pharmaceutical Sciences
Database: PERIÓDICA
System number: 000452130
ISSN: 1984-8250
Authors: 1
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Institutions: 1King Khalid University, College of Pharmacy, Abha, Asir. Arabia Saudita
2King Khalid University, College of Nursing, Abha, Asir. Arabia Saudita
3Shaqra University, College of Pharmacy, Shaqra. Arabia Saudita
Year:
Volumen: 58
Country: Brasil
Language: Inglés
Document type: Artículo
Approach: Experimental, aplicado
English abstract Neuropathic pain is generally characterised by an abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). The present study was designed to investigate the effect of trazodone (5mg/kg and 10mg/kg) on peripheral neuropathic pain induced by partial sciatic nerve ligation in rats. Mechanical hyperalgesia, cold allodynia and thermal hyperalgesia were assessed by performing the pinprick, acetone, and hot plate tests, respectively. Biochemically, lipid peroxidation level and total calcium levels were measured. However, trazodone administration (5 and 10 mg/ kg i.p.) for 21days significantly diminished partial sciatic nerve ligation-induced neuropathic pain along with areduction in oxidative stress and calcium levels. The results of the present study suggest that trazodone is effective in attenuating partial sciatic nerve ligation-inducedpainful neuropathic states, which may be attributed to decreased oxidative stress and calcium levels
Disciplines: Medicina
Keyword: Neurología,
Farmacología,
Medicina experimental,
Dolor neuropático,
Hiperalgesia,
Trazodona,
Ratas
Keyword: Neurology,
Pharmacology,
Experimental medicine,
Neuropathic pain,
Hyperalgesia,
Trazodone,
Rats
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