| Revista: | Brazilian Journal of Pharmaceutical Sciences |
| Base de datos: | PERIÓDICA |
| Número de sistema: | 000452130 |
| ISSN: | 1984-8250 |
| Autores: | Vasudevan, Rajalakshimi1 Kandasamy, Geetha1 Almaghaslah, Dalia1 Almanasef, Mona1 Alqahatani, Ali1 Aldahish, Afaf1 Venkatesan, Krishnaraju1 Paulsamy, Premalatha2 Maheswari, C3 Wahab, Shadma1 |
| Instituciones: | 1King Khalid University, College of Pharmacy, Abha, Asir. Arabia Saudita 2King Khalid University, College of Nursing, Abha, Asir. Arabia Saudita 3Shaqra University, College of Pharmacy, Shaqra. Arabia Saudita |
| Año: | 2022 |
| Volumen: | 58 |
| País: | Brasil |
| Idioma: | Inglés |
| Tipo de documento: | Artículo |
| Enfoque: | Experimental, aplicado |
| Resumen en inglés | Neuropathic pain is generally characterised by an abnormal sensation (dysesthesia), an increased response to painful stimuli (hyperalgesia), and pain in response to a stimulus that does not normally provoke pain (allodynia). The present study was designed to investigate the effect of trazodone (5mg/kg and 10mg/kg) on peripheral neuropathic pain induced by partial sciatic nerve ligation in rats. Mechanical hyperalgesia, cold allodynia and thermal hyperalgesia were assessed by performing the pinprick, acetone, and hot plate tests, respectively. Biochemically, lipid peroxidation level and total calcium levels were measured. However, trazodone administration (5 and 10 mg/ kg i.p.) for 21days significantly diminished partial sciatic nerve ligation-induced neuropathic pain along with areduction in oxidative stress and calcium levels. The results of the present study suggest that trazodone is effective in attenuating partial sciatic nerve ligation-inducedpainful neuropathic states, which may be attributed to decreased oxidative stress and calcium levels |
| Disciplinas: | Medicina |
| Palabras clave: | Neurología, Farmacología, Medicina experimental, Dolor neuropático, Hiperalgesia, Trazodona, Ratas |
| Keyword: | Neurology, Pharmacology, Experimental medicine, Neuropathic pain, Hyperalgesia, Trazodone, Rats |
| Texto completo: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
