| Journal: | Brazilian Journal of Pharmaceutical Sciences |
| Database: | PERIÓDICA |
| System number: | 000452222 |
| ISSN: | 1984-8250 |
| Authors: | Türkmen, Neşe Başak1 Yüce, Hande1 Taşlıdere, Aslı2 Şahin, Yasemin3 Ayhan, İdris4 Unuvar, Songül1 Çiftçi, Osman3 |
| Institutions: | 1Inonu University, Faculty of Pharmacy, Malatya. Turquía 2Inonu University, Faculty of Medicine, Malatya. Turquía 3Pamukkale University, Faculty of Medicine, Denizli. Turquía 4The Scientific and Technological Research Council of Turkey, Department of Health Sciences, Ankara. Turquía |
| Year: | 2022 |
| Volumen: | 58 |
| Country: | Brasil |
| Language: | Inglés |
| Document type: | Artículo |
| Approach: | Experimental, aplicado |
| English abstract | The aim of the present study is to investigate the cardioprotective effects of 18β-glycyrrhetinic acid (18β -GA) against oxidative and histological damage caused by global cerebral ischemia/ reperfusion (I/R) in C57BL/J6 mice. All male mice (n:40) were randomly divided into four groups: (1) sham-operated (Sham), (2) I/R, (3) 18β-GA, and (4) 18β -GA+I/R. Ischemia was not applied to the sham and 18β-GA groups. In the I/R group, the bilateral carotid arteries were clipped for 15 min to induce ischemia, and the mice were treated with the vehicle for 10 days. In the 18β-GA group, the mice were given 18β-GA (100 mg/kg) for 10 days following a median incision without carotid occlusion. In the 18β-GA+I/R group, the ischemic procedure performed to the I/R model was applied to the animals and afterwards they were intraperitoneally (i.p.) treated with 18β-GA (100 mg/kg) for 10 days. It was found that global cerebral I/R increased TBARS levels and decreased antioxidant parameters. The 18β-GA treatment decreased the level of TBARS and increased GSH, GPx, CAT, SOD activities. Also, the control group cardiac tissue samples were observed to have a normal histological appearance with the Hematoxylin-Eosin staining method. Histopathological damage was observed in the heart tissue samples belonging to the I/R group. The 18β-GA treatment ameliorates oxidative and histological injury in the heart tissue after global ischemia reperfusion, and may be a beneficial alternative treatment |
| Disciplines: | Medicina, Química |
| Keyword: | Neurología, Farmacología, Medicina experimental, Isquemia cerebral, Acido glicirretínico, Estrés oxidativo, Lesión cardiaca, Ratones |
| Keyword: | Neurology, Pharmacology, Experimental medicine, Brain ischemia, Glycyrrhetinic acid, Oxidative stress, Heart lesion, Mice |
| Full text: | Texto completo (Ver HTML) Texto completo (Ver PDF) |
